Effects of thioperamide, a histamine H3 antagonist, on the step-through passive avoidance response and histidine decarboxylase activity in senescence-accelerated mice

Ken Ichi Meguro, Kazuhiko Yanai, Naruhiko Sakai, Eiko Sakurai, Kazutaka Maeyama, Hidetada Sasaki, Takehiko Watanabe

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

The effect of thioperamide, a histamine H3 receptor antagonist, on learning and memory was studied in the senescence-accelerated mice-prone strain (SAM-P/8) and normal-rate aging strain (SAM-R/1). In a passive avoidance test, SAM-P/8 mice of 12 months showed significant impairment of learning and memory compared with SAM-R/1 mice of the same age. Thioperamide significantly improved the response latency in SAM-P/8 mice when injected intraperitoneally at a dose of 15 mg/kg. The histidine decarboxylase (HDC) activity in the forebrain was significantly lower in SAM-P/8 mice than in SAM-R/1 mice. Thioperamide administration significantly potentiated HDC activity in the forebrain of SAM-P/8 mice as well as improving learning and memory. These results suggest that central histaminergic neurons may be involved in learning and memory impairment of SAM-P/8 mice, although other possibilities are not ruled out.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume50
Issue number3
DOIs
Publication statusPublished - 1995 Mar

Keywords

  • Acquisition memory
  • Brain
  • Brain histamine content
  • Histamine
  • Histamine H receptor
  • Passive avoidance
  • Thioperamide

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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