Effects of the small molecule dorsomorphin on intracellular signaling

Tadaaki Kudo, Hiroyasu Kanetaka, Kazutoshi Mizuno, Yasuhiro Ryu, Ye Zhang, Mitsuhiro Kano, Yoshinaka Shimizu, Haruhide Hayashi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The small molecule dorsomorphin, also known as compound C, is a cell-permeable pyrazolopyrimidine derivative, which acts as a potent and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK). Recent studies indicated that several molecules with functions in other signaling pathways, including bone morphogenetic protein (BMP) signaling, are novel targets of dorsomorphin. This report focuses on two major targets of dorsomorphin and provides insight into the use of dorsomorphin in the analysis of intracellular signaling.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Pages131-133
Number of pages3
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
DOIs
Publication statusPublished - 2012 Jan 1

Keywords

  • Amp-activated protein kinase (AMPK)
  • Bone morphogenetic protein (BMP)
  • Dorsomorphin

ASJC Scopus subject areas

  • Dentistry(all)

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