Effects of the Pathway of Bile Flow on the Digestion of Fat and the Release of Gastrointestinal Hormones

Mikio Imamura, Michinaga Takahashi, Iwao Sasaki, Hidemi Yamauchi, Toshio Sato

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The effects of an altered pathway of bile flow upon fat metabolism and gastrointestinal hormone release were investigated in patients undergoing biliary reconstruction procedures or external biliary drainage. After ingestion of a fat‐enriched meal, patients with jejunal interposition hepaticoduodenostomy showed the same patterns as controls, with similar levels of plasma tri‐glyceride and gastrointestinal hormones. On the other hand, patients with Roux‐Y hepaticojejunostomy or external biliary drainage revealed the impairment of fat metabolism, although the response patterns were different. As for the changes in gastrointestinal hormones in the two groups, both gastric inhibitory polypeptide (GIP) and insulin levels were reduced, whereas glucagon‐like immunoreactivity (GH) levels rose, especially in the external biliary drainage group. It is considered that the disturbance of fat metabolism, in cases of internal or external biliary diversion, is closely related to changes in GIP, insulin, and GLI release, in addition to the impairment of mixed micelle formation by bile and of hydrolysis by pancreatic enzymes.

Original languageEnglish
Pages (from-to)386-392
Number of pages7
JournalThe American journal of gastroenterology
Volume83
Issue number4
DOIs
Publication statusPublished - 1988 Apr

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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