Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[β- 11C]DOPA: A stabilizing effect for dopaminergic neurotransmission?

Hiroshi Ito, Harumasa Takano, Hidehiko Takahashi, Ryosuke Arakawa, Michie Miyoshi, Fumitoshi Kodaka, Masaki Okumura, Tatsui Otsuka, Tetsuya Suhara

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Effects of antipsychotic drugs have widely been considered to be mediated by blockade of postsynaptic dopamine D2 receptors. Effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission might also be related to therapeutic effects of antipsychotics. To investigate the effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission in relation with occupancy of dopamine D2 receptors, changes in dopamine synthesis capacity by antipsychotics and occupancy of dopamine D2 receptors were measured by positron emission tomography (PET) in healthy men. PET studies using [ 11C]raclopride and L-[β-11C]DOPA were performed under resting condition and oral administration of single dose of the antipsychotic drug risperidone on separate days. Although occupancy of dopamine D2 receptors corresponding dose of risperidone was observed, the changes in dopamine synthesis capacity by the administration of risperidone were not significant, nor was the relation between the occupancy of dopamine D2 receptors and these changes. A significant negative correlation was observed between the baseline dopamine synthesis capacity and the changes in dopamine synthesis capacity by risperidone, indicating that this antipsychotic can be assumed to stabilize the dopamine synthesis capacity. The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity.

Original languageEnglish
Pages (from-to)13730-13734
Number of pages5
JournalJournal of Neuroscience
Volume29
Issue number43
DOIs
Publication statusPublished - 2009 Oct 28
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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