Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat

Chihiro Ito, Haowei Shen, Hiroshi Toyota, Yasuhiko Kubota, Eiko Sakurai, Takehiko Watanabe, Mitsumoto Sato

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The effects of acute and chronic restraint stresses on the brain histamine level and histamine N-methyltransferase activity in Fischer rat brain were studied. The acute restraint stress increased the histamine levels in the diencephalon and nucleus accumbens, and increased the histamine N- methyltransferase activities in the nucleus accumbens and striatum. The chronic restraint stress also increased histamine N-methyltransferase activities in the nucleus accumbens and striatum. These results indicate that the acute and chronic restraint stresses increase the brain histamine turnover, which may partly relate to the vulnerability for stress-induced anxiety and depression.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalNeuroscience Letters
Volume262
Issue number2
DOIs
Publication statusPublished - 1999 Mar 5

Keywords

  • Fischer rat brain
  • Histamine
  • Histamine N-methyltransferase
  • Restraint stresses
  • Stress vulnerability

ASJC Scopus subject areas

  • Neuroscience(all)

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