Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice

Kazuki Morohoshi; Katsumi Yoshida; Yoshinori Nakagawa; Saeko Hoshikawa; Hiroshi Ozaki; Yurie Takahashi; Sadayoshi Ito; Kouki Mori

doi:10.1016/j.cellimm.2011.05.005

Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice

Kazuki Morohoshi, Katsumi Yoshida, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito, Kouki Mori

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1. mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Cellular Immunology
Volume	270
Issue number	1
DOIs	https://doi.org/10.1016/j.cellimm.2011.05.005
Publication status	Published - 2011

Keywords

Am80
Hashimoto's thyroiditis
Iodide
Nonobese diabetic mouse
Retinoid

ASJC Scopus subject areas

Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellimm.2011.05.005

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title = "Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice",

abstract = "We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1. mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.",

keywords = "Am80, Hashimoto's thyroiditis, Iodide, Nonobese diabetic mouse, Retinoid",

author = "Kazuki Morohoshi and Katsumi Yoshida and Yoshinori Nakagawa and Saeko Hoshikawa and Hiroshi Ozaki and Yurie Takahashi and Sadayoshi Ito and Kouki Mori",

note = "Funding Information: The authors thank Dr. Koichi Shudo (Research Foundation Itsuu Laboratory) for providing the feeding pellets containing Am80 and valuable suggestion. This study was supported in part by grant-in-aid from Research Foundation Itsuu Laboratory. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2011",

doi = "10.1016/j.cellimm.2011.05.005",

language = "English",

volume = "270",

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journal = "Cellular Immunology",

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AU - Morohoshi, Kazuki

AU - Yoshida, Katsumi

AU - Nakagawa, Yoshinori

AU - Hoshikawa, Saeko

AU - Ozaki, Hiroshi

AU - Takahashi, Yurie

AU - Ito, Sadayoshi

AU - Mori, Kouki

N1 - Funding Information: The authors thank Dr. Koichi Shudo (Research Foundation Itsuu Laboratory) for providing the feeding pellets containing Am80 and valuable suggestion. This study was supported in part by grant-in-aid from Research Foundation Itsuu Laboratory. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2011

Y1 - 2011

N2 - We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1. mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.

AB - We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1. mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.

KW - Am80

KW - Hashimoto's thyroiditis

KW - Iodide

KW - Nonobese diabetic mouse

KW - Retinoid

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Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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