Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice

Kazuki Morohoshi, Katsumi Yoshida, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito, Kouki Mori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1. mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCellular Immunology
Volume270
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Am80
  • Hashimoto's thyroiditis
  • Iodide
  • Nonobese diabetic mouse
  • Retinoid

ASJC Scopus subject areas

  • Immunology

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