Effects of sevoflurane on electrocorticography in patients with intractable temporal lobe epilepsy

T. Endo, K. Sato, H. Shamoto, T. Yoshimoto

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Fentanyl-droperidol technique is the choice for epilepsy surgery. It requires intraoperative electrocorticography (ECoG), but a large dose of fentanyl is needed for this technique. On the other hand, sevoflurane reportedly may be beneficial for intraoperative ECoG. To reveal whether the combined technique with fentanyl and sevoflurane is beneficial for epilepsy surgery, we investigated ECoG in 10 patients with intractable temporal lobe epilepsy without sevoflurane, with 0.5 minimum alveolar concentration (MAC) sevoflurane, and with 1.5 MAC sevoflurane under fentanyl-based anesthesia. The mean number of spikes for 1 minute decreased from 38.3 to 14.1 after 1.5 MAC sevoflurane was induced, which was statistically significant (P < .05). Our results showed that balanced technique with neurolepto-analgesia (NLA) and sevoflurane is not suitable for epilepsy surgery requiring intraoperative ECoG. When epilepsy surgeries are performed under sevoflurane anesthesia, it is important to consider that sevoflurane may suppress electric activities when it is used with other anesthetic agents.

Original languageEnglish
Pages (from-to)59-62
Number of pages4
JournalJournal of Neurosurgical Anesthesiology
Issue number1
Publication statusPublished - 2002
Externally publishedYes


  • Electrocorticography
  • Fentanyl
  • Sevoflurane
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Effects of sevoflurane on electrocorticography in patients with intractable temporal lobe epilepsy'. Together they form a unique fingerprint.

Cite this