Effects of (S)-α-Fluoromethylhistidine and (R)-α-Methylhistamine on locomotion of W/Wν mice

Sakai Naruhiko Sakai, Yamazaki Seiji Yamazaki, Onodera Kenji Onodera, Yanai Kazuhiko Yanai, Maeyama Kazutaka Maeyama, Watanabe Takehiko Watanabe

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We studied the effects of inactivators of the central histaminergic neuron system, (R)-α-methylhistamine, a histamine H3 receptor agonist, and (S)-α-fluoromethylhistidine, a histamine synthesis inhibitor, on locomotor activity and brain histamine content of mast cell-deficient W/Wν mice using a recently developed high-performance liquid chromatography system coupled with a fluorometric detector. IP injection of (R)-α-methylhistamine (6-50 mg/kg) increased brain histamine content after 1 h but caused no significant change in locomotor activity. IP injection of (S)-α-fluoromethylhistidine decreased brain histamine content at doses of 6-50 mg/kg and locomotor activity at doses of 12.5-50 mg/kg. However, locomotor activity was decreased significantly (in Student's t-test) by sequential administrations of (S)-α-fluoromethylhistidine (6 mg/kg) and (R)-α-methylhistamine (12.5 or 25 mg/kg), but not by (S)-α-fluoromethylhistidine (6 mg/kg) and other doses of (R)-α-methylhistamine (6 or 50 mg/kg). These results support the hypothesis that the central histaminergic neuron system is involved in the control of spontaneous locomotion or alertness.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume46
Issue number1
DOIs
Publication statusPublished - 1993 Sep

Keywords

  • (R)-α-Methylhistamine
  • (S)-α-Fluoromethylhistidine
  • Histamine
  • Histamine H receptor
  • Locomotor activity
  • Mast cell-deficient (W/W) mouse

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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