TY - JOUR
T1 - Effects of (S)-α-Fluoromethylhistidine and (R)-α-Methylhistamine on locomotion of W/Wν mice
AU - Naruhiko Sakai, Sakai
AU - Seiji Yamazaki, Yamazaki
AU - Kenji Onodera, Onodera
AU - Kazuhiko Yanai, Yanai
AU - Kazutaka Maeyama, Maeyama
AU - Takehiko Watanabe, Watanabe
N1 - Funding Information:
The authors thank Sumltomo Pharmaceutical Co. (Osaka, Japan) and Dr. J. Kollonitsch (Merck Sharp & Dohme, Rahway, N J) for generous gifts of (R)-a-methylhtstamine and FMH, respectively. They also thank A. Sakurai for help m experiments. This work was partially supported by Grants-in-Atd from the Japanese Ministry of Education, Science and Culture (63065004), the Kowa Research Foundation, CIBA-GEIGY Foundation (Japan), and Suzuken Life Soence Foundation.
PY - 1993/9
Y1 - 1993/9
N2 - We studied the effects of inactivators of the central histaminergic neuron system, (R)-α-methylhistamine, a histamine H3 receptor agonist, and (S)-α-fluoromethylhistidine, a histamine synthesis inhibitor, on locomotor activity and brain histamine content of mast cell-deficient W/Wν mice using a recently developed high-performance liquid chromatography system coupled with a fluorometric detector. IP injection of (R)-α-methylhistamine (6-50 mg/kg) increased brain histamine content after 1 h but caused no significant change in locomotor activity. IP injection of (S)-α-fluoromethylhistidine decreased brain histamine content at doses of 6-50 mg/kg and locomotor activity at doses of 12.5-50 mg/kg. However, locomotor activity was decreased significantly (in Student's t-test) by sequential administrations of (S)-α-fluoromethylhistidine (6 mg/kg) and (R)-α-methylhistamine (12.5 or 25 mg/kg), but not by (S)-α-fluoromethylhistidine (6 mg/kg) and other doses of (R)-α-methylhistamine (6 or 50 mg/kg). These results support the hypothesis that the central histaminergic neuron system is involved in the control of spontaneous locomotion or alertness.
AB - We studied the effects of inactivators of the central histaminergic neuron system, (R)-α-methylhistamine, a histamine H3 receptor agonist, and (S)-α-fluoromethylhistidine, a histamine synthesis inhibitor, on locomotor activity and brain histamine content of mast cell-deficient W/Wν mice using a recently developed high-performance liquid chromatography system coupled with a fluorometric detector. IP injection of (R)-α-methylhistamine (6-50 mg/kg) increased brain histamine content after 1 h but caused no significant change in locomotor activity. IP injection of (S)-α-fluoromethylhistidine decreased brain histamine content at doses of 6-50 mg/kg and locomotor activity at doses of 12.5-50 mg/kg. However, locomotor activity was decreased significantly (in Student's t-test) by sequential administrations of (S)-α-fluoromethylhistidine (6 mg/kg) and (R)-α-methylhistamine (12.5 or 25 mg/kg), but not by (S)-α-fluoromethylhistidine (6 mg/kg) and other doses of (R)-α-methylhistamine (6 or 50 mg/kg). These results support the hypothesis that the central histaminergic neuron system is involved in the control of spontaneous locomotion or alertness.
KW - (R)-α-Methylhistamine
KW - (S)-α-Fluoromethylhistidine
KW - Histamine
KW - Histamine H receptor
KW - Locomotor activity
KW - Mast cell-deficient (W/W) mouse
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U2 - 10.1016/0091-3057(93)90323-L
DO - 10.1016/0091-3057(93)90323-L
M3 - Article
C2 - 8255927
AN - SCOPUS:0027488425
VL - 46
SP - 95
EP - 99
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 1
ER -