Effects of (S) - α -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice

Naruhiko Sakai, Kenji Onodera, Kazutaka Maeyama, Kazuhiko Yanai, Takehiko Watanabe

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We examined the effects of (S) - α -fluoromethylhistidine (FMH), an inhibitor of histidine decarboxylase, and metoprine, an inhibitor of histamine N-methyltransferase, on the locomotor activity and the brain histamine content of ICR mice. The brain histamine content was decreased by FMH (12.5 or 50 mg/kg, i.p.) and increased by metoprine (4 mg/kg, i.p.). Under these conditions, the locomotor activity and the number of rearing were significantly decreased and increased by FMH and metoprine, respectively. The higher the brain histamine content, the greater the locomotor activity and vice versa. In a previous paper [Sakai et al., Life Sciences, 48, 2397-2404 (1991)], we showed that thioperamide, a histamine H3 antagonist, which enhances the release of histamine from histaminergic neurons, in doses of 12.5 and 25 mg/kg, i.p. increases the locomotor activity, whereas it decreases the brain histamine content. Taken together, these results support the hypothesis that central histaminergic neurons may be involved in the control of state of locomotion and rearing.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalLife Sciences
Volume51
Issue number6
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Effects of (S) - α -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice'. Together they form a unique fingerprint.

Cite this