Effects of rose bengal on cavitation generation in gel phantom investigated using high-speed camera

Jun Yasuda, Takuya Miyashita, Shin Yoshizawa, Shin Ichiro Umemura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Acoustic cavitation bubbles are microbubbles generated by the highly negative pressure of ultrasound. They are known to enhance the thermal bioeffect of high-intensity focused ultrasound (HIFU) treatment. Other than the use of the thermal bioeffect, sonodynamic treatment using the sonochemical bioeffect of ultrasound has been proposed. In sonodynamic treatment, a sonosensitizer is activated through the collapse of cavitation bubbles to induce a therapeutic effect sonochemically. Rose Bengal (RB) has the potential to be such a sonosensitizer. Highly efficient as well as controlled generation of cavitation bubbles is crucial for realizing effective as well as safe sonodynamic treatment. The effect of RB on cavitation generation was investigated to achieve such controlled generation. The amount and behavior of the cavitation bubbles generated by a triggered HIFU sequence in the presence of RB were observed using a high-speed camera for estimating the effect of RB. Results showed that RB increased the area of the cavitation cloud and the lifetime of sustained cavitation bubbles.

Original languageEnglish
Article number07KF20
JournalJapanese journal of applied physics
Issue number7 SPEC. ISSUE
Publication statusPublished - 2014 Jul

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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