Effects of Rhinovirus Infection on the Adherence of Streptococcus pneumoniae to Cultured Human Airway Epithelial Cells

Satoshi Ishizuka, Mutsuo Yamaya, Tomoko Suzuki, Hidenori Takahashi, Shiroh Ida, Takahiko Sasaki, Daisuke Inoue, Kiyohisa Sekizawa, Hidekazu Nishimura, Hidetada Sasaki

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-κB (NF-κB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-κB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection.

Original languageEnglish
Pages (from-to)1928-1939
Number of pages12
JournalJournal of Infectious Diseases
Volume188
Issue number12
DOIs
Publication statusPublished - 2003 Dec 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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