EFFECTS OF RECOMBINANT HUMAN ERYTHROPOIETIN ON BLOOD PRESSURE AND RENAL FUNCTION IN SHR WITH CHRONIC RENAL FAILURE

Masahiro Kohzuki, Minoru Yasujima, Masayuki Kanazawa, Kazunori Yoshida, Tokutaro Sato, Keishi Abe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

1. The effects of chronic administration of erythropoietin (EPO) on blood pressure and renal function in rats with ablation of renal mass were assessed. 2. Spontaneously hypertensive rat were subjected to 5/6 nephrectomy (5/6Nx). Four weeks after the operation, the rats were randomly allocated to vehicle, EPO 20 IU/kg i.p., or EPO 100 W/kg i.p. (both given twice a week) for 4 weeks. 3. Marked anaemia was noted in SHR‐5/6Nx. EPO caused a significant increase in haematocrit at a high dose but not at a low dose. A dose dependent relationship was noted in the EPO‐induced rise in the systolic blood pressure. 4. EPO dose‐dependently increased urinary protein excretion. It also increased blood urea nitrogen and serum creatinine levels. 5. These results suggest that EPO ameliorates anaemia and severely accelerates renal failure in SHR‐5/6Nx. They also suggest that anaemia can be a haemodynamieally favourable adaptation to chronic renal disease and that its correction may have adverse renal haemodynamic and structural consequences.

Original languageEnglish
Pages (from-to)S165-S166
JournalClinical and Experimental Pharmacology and Physiology
Volume22
DOIs
Publication statusPublished - 1995 Nov

Keywords

  • chronic treatment
  • erythropoietin
  • haematocrit
  • nephrectomy
  • proteinuria
  • spontaneously hypertensive rat

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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