Effects of Qing Fei Tang (TJ-90) on aspiration pneumonia in mice

K. Iwasaki, Q. Wang, N. Satoh, S. Yoshida, T. Akaike, K. Sekizawa, H. Maeda, H. Sasaki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The effects of Qing Fei Tang (Sei-hai To in Japanese), a Chinese traditional medical mixture, on aspiration pneumonia were studied using mice inoculated with both Streptococcus pneumoniae and gastric juice as aspiration pncumoniae models. Daily (4 weeks) oral usage of Qing Fei Tang before inoculation reduced remarkably the mortality rate of mice. In this aspiration pneumonia model, xanthine oxidase (XO) activity in the lung tissues was elevated, but this elevation was remarkably decreased by use of Qing Fei Tang. These results suggest that Qing Fei Tang pretreatment can reduce oxygen radical production in inflammed lungs and may reduce the mortality for aspiration pneumonia.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalPhytomedicine
Volume6
Issue number2
DOIs
Publication statusPublished - 1999 May
Externally publishedYes

Keywords

  • Aspiration pneumonia
  • Free radical
  • Gastric juice
  • Pyran-superoxide dismutase (pyran-SOD)
  • Qing Fei Tang (Sei-Hai To)
  • Traditional Chinese medicine
  • Xanthine oxidase (XO)

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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