Effects of prolyl hydroxylase inhibition on arterial collagen synthesis and blood pressure in hypertensive rats

Manabu Fukumoto, N. Himeno, M. Asai, O. Midorikawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Changes in arterial collagen synthesis and the effects of P-1894B, a potent inhibitor of prolyl hydroxylase, were investigated on rat hypertension, induced by deoxycorticosterone acetate (DOCA) and salt. In DOCA-salt hypertensive rats, prolyl hydroxylase activity increased significantly in the abdominal aorta and in the mesenteric artery. Incorporation of 14C-proline into the thoracic aorta, abdominal aorta and mesenteric artery was higher and the hydroxyproline content of the abdominal aorta and mesenteric artery was higher than in the control rats. Treatment with P-1894B significantly inhibited prolyl hydroxylase activity, reduced arterial collagen synthesis, but did not prevent or reverse hypertension.

Original languageEnglish
Pages (from-to)255-263
Number of pages9
JournalPharmacology
Volume29
Issue number5
DOIs
Publication statusPublished - 1984 Jan 1

ASJC Scopus subject areas

  • Pharmacology

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