TY - JOUR
T1 - Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity
AU - Maruyama, Takashi
AU - Shiba, Takahiro
AU - Iizuka, Hiromi
AU - Matsuda, Tomoko
AU - Kurohane, Kohta
AU - Imai, Yasuyuki
PY - 2007
Y1 - 2007
N2 - Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD11b + dendritic cells (DC). DEP has relatively weak activity as to FITC-positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC-positive CD8alpha+ DC in draining lymph nodes. We also found enhanced production of interleukin-4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters.
AB - Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD11b + dendritic cells (DC). DEP has relatively weak activity as to FITC-positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC-positive CD8alpha+ DC in draining lymph nodes. We also found enhanced production of interleukin-4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters.
KW - Contact hypersensitivity
KW - Dendritic cells
KW - IL-4
KW - Phthalate esters
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U2 - 10.1111/j.1348-0421.2007.tb03914.x
DO - 10.1111/j.1348-0421.2007.tb03914.x
M3 - Article
C2 - 17380052
AN - SCOPUS:33947425557
VL - 51
SP - 321
EP - 326
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 3
ER -