Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity

Takashi Maruyama, Takahiro Shiba, Hiromi Iizuka, Tomoko Matsuda, Kohta Kurohane, Yasuyuki Imai

    Research output: Contribution to journal › Article › peer-review

    21 Citations (Scopus)

    Abstract

    Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD11b + dendritic cells (DC). DEP has relatively weak activity as to FITC-positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC-positive CD8alpha+ DC in draining lymph nodes. We also found enhanced production of interleukin-4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters.

    Original languageEnglish
    Pages (from-to)321-326
    Number of pages6
    JournalMICROBIOLOGY and IMMUNOLOGY
    Volume51
    Issue number3
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Contact hypersensitivity
    • Dendritic cells
    • IL-4
    • Phthalate esters

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology

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