Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity

Takashi Maruyama; Takahiro Shiba; Hiromi Iizuka; Tomoko Matsuda; Kohta Kurohane; Yasuyuki Imai

doi:10.1111/j.1348-0421.2007.tb03914.x

Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity

Takashi Maruyama, Takahiro Shiba, Hiromi Iizuka, Tomoko Matsuda, Kohta Kurohane, Yasuyuki Imai

Research output: Contribution to journal › Article

21 Citations (Scopus)

Abstract

Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD11b ⁺ dendritic cells (DC). DEP has relatively weak activity as to FITC-positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC-positive CD8alpha⁺ DC in draining lymph nodes. We also found enhanced production of interleukin-4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	51
Issue number	3
DOIs	https://doi.org/10.1111/j.1348-0421.2007.tb03914.x
Publication status	Published - 2007

Keywords

Contact hypersensitivity
Dendritic cells
IL-4
Phthalate esters

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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Maruyama, T., Shiba, T., Iizuka, H., Matsuda, T., Kurohane, K., & Imai, Y. (2007). Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity. MICROBIOLOGY and IMMUNOLOGY, 51(3), 321-326. https://doi.org/10.1111/j.1348-0421.2007.tb03914.x

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AU - Maruyama, Takashi

AU - Shiba, Takahiro

AU - Iizuka, Hiromi

AU - Matsuda, Tomoko

AU - Kurohane, Kohta

AU - Imai, Yasuyuki

PY - 2007

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AB - Phthalate esters with short alkyl chains, such as di-ethyl (DEP), di-n-propyl (DPP), and di-butyl phthalate (DBP), have adjuvant effects on an FITC-induced contact hypersensitivity mouse model. The adjuvant effects of DPP and DBP are associated with enhanced trafficking of FITC-presenting CD11b + dendritic cells (DC). DEP has relatively weak activity as to FITC-positive cell migration. Here we demonstrated that DBP and DPP also increased the number of FITC-positive CD8alpha+ DC in draining lymph nodes. We also found enhanced production of interleukin-4 in draining lymph nodes after FITC sensitization with DEP, DPP, or DBP, suggesting an additional adjuvant mechanism of phthalate esters.

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