Effects of phase II cardiac rehabilitation of insulin resistance and myocardial remodeling in patients with acute myocardial infarction

M. Kohzuki, M. Nagasaka, P. Dobšák, H. Svačinová, J. Siegelová, J. E. Wolf

Research output: Contribution to journalArticlepeer-review

Abstract

We have designed a new 2-week hospitalized phase II Cardiac Rehabilitation (CR) program in Japan. The purpose of the present study is to determine long-term effects on physical parameters, especially insulin resistance and myocardial remodeling in patients with acute myocardial infarction. Twenty-five patients (20 men, 5 women, mean age: 52±11years, peak CK 2378±1881 IU/l, mean EF 60±18%) with AMI were enrolled in this program. Plasma propeptide of type I procollagen (PICP), HOMA-R and proinsulin were evaluated. The physical status was assessed by the exercise tolerance (AT and peak VO2), exercise frequency, serum lipid profiles and BMI. All the parameters were evaluated before, 1, 6 and 12 months after the participation in the program. Serum lipid profiles (HDL cholesterol, triglyceride), BMI, peak VO2 and AT were improved significantly, PICP was stable at the 1, 6 and 12 months follow-up. Eighty percent of patients had regular exercise activity (REA). There was no significant difference in PICP between REA and the sedentary subjects. Proinsulin and HOMA-R were stable at the 1, 6 and 12 months follow-up. The change in HOMA-R was not related to exercise tolerance; it strongly correlated with the change in BMI (r=0.61). These results suggest that Phase II CR program does not accelerate myocardial remodeling and our 2-week hospitalized Phase II CR program contributes to not only maintain insulin sensitivity but also to improve the management of other cardiac risk factors.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Volume81
Issue number3
Publication statusPublished - 2008

Keywords

  • Cardiovascular risk
  • Diabetes
  • Exercise
  • Myocardial infarction
  • Rehabilitation

ASJC Scopus subject areas

  • Medicine(all)

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