Effects of NKH477 on renal nerve stimulation-induced responses in anesthetized dogs

Masayuki Tanahashi, Sunao Hara, Kazutomo Saitoh, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We evaluated the effects of an adenylate cyclase activator, N,N-dimetyl-β-alanine[3R-(3α,4αβ,5β,6β,6aα,10α,10aβ,10bα)]-5(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride (NKH477), on neural control of renal functions in anesthetized dogs. Renal nerve stimulation (2 Hz) increased renal norepinephrine efflux and reduced renal blood flow, glomerular filtration rate, urine flow rate, urinary Na+ excretion and fractional Na+ excretion. Intrarenal arterial infusion of NKH477 (300 ng/kg/min) suppressed the stimulation-induced reductions in renal blood flow and glomerular filtration rate and attenuated the reductions in urine flow rate and urinary Na+ excretion but not the changes in renal norepinephrine efflux and fractional Na+ excretion. Infusion of NKH477 did not affect the urinary responses induced by renal nerve stimulation at a lower frequency (0.5-1 Hz) which had little influence on renal blood flow and glomerular filtration rate. The present results demonstrate that NKH477 inhibits renal vasoconstriction and hypofiltration but not the enhanced tubular Na+ reabsorption during activation of the renal sympathetic nervous system. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalEuropean Journal of Pharmacology
Volume384
Issue number1
DOIs
Publication statusPublished - 1999 Nov 12

Keywords

  • Dog
  • Glomerular filtration
  • NKH477
  • Renal nerve
  • Urinary Na excretion

ASJC Scopus subject areas

  • Pharmacology

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