Abstract
1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.
Original language | English |
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Pages (from-to) | 513-515 |
Number of pages | 3 |
Journal | Clinical and Experimental Pharmacology and Physiology |
Volume | 27 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2000 Jul 11 |
Externally published | Yes |
Keywords
- Adenylate cyclase
- Cyclic AMP
- Dog
- Endothelin-1
- Glomerular filtration rate
- Kidney
- NKH477
- Renal blood flow
- Urinary Na excretion
ASJC Scopus subject areas
- Physiology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)