Abstract
1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.
| Original language | English |
|---|---|
| Pages (from-to) | 513-515 |
| Number of pages | 3 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Volume | 27 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2000 Jul 11 |
Keywords
- Adenylate cyclase
- Cyclic AMP
- Dog
- Endothelin-1
- Glomerular filtration rate
- Kidney
- NKH477
- Renal blood flow
- Urinary Na excretion
ASJC Scopus subject areas
- Physiology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Cite this
Hara, S., Tanahashi, M., Yoshida, M., Suzuki-Kusaba, M., Hisa, H., & Satoh, S. (2000). Effects of NKH477 on endothelin-1-induced renal responses in anaesthetized dogs. Clinical and Experimental Pharmacology and Physiology, 27(7), 513-515. https://doi.org/10.1046/j.1440-1681.2000.03282.x