Effects of NKH477 on endothelin-1-induced renal responses in anaesthetized dogs

Sunao Hara; Masayuki Tanahashi; Makoto Yoshida; Mizue Suzuki-Kusaba; Hiroaki Hisa; Susumu Satoh

doi:10.1046/j.1440-1681.2000.03282.x

Effects of NKH477 on endothelin-1-induced renal responses in anaesthetized dogs

Sunao Hara, Masayuki Tanahashi, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

Clinical Research, Innovation and Education Center

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.

Original language	English
Pages (from-to)	513-515
Number of pages	3
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	27
Issue number	7
DOIs	https://doi.org/10.1046/j.1440-1681.2000.03282.x
Publication status	Published - 2000 Jul 11

Keywords

Adenylate cyclase
Cyclic AMP
Dog
Endothelin-1
Glomerular filtration rate
Kidney
NKH477
Renal blood flow
Urinary Na excretion

ASJC Scopus subject areas

Physiology
Pharmacology (medical)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1046/j.1440-1681.2000.03282.x

Cite this

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abstract = "1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.",

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AU - Hara, Sunao

AU - Tanahashi, Masayuki

AU - Yoshida, Makoto

AU - Suzuki-Kusaba, Mizue

AU - Hisa, Hiroaki

AU - Satoh, Susumu

PY - 2000/7/11

Y1 - 2000/7/11

N2 - 1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.

AB - 1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.

KW - Adenylate cyclase

KW - Cyclic AMP

KW - Dog

KW - Endothelin-1

KW - Glomerular filtration rate

KW - Kidney

KW - NKH477

KW - Renal blood flow

KW - Urinary Na excretion

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Effects of NKH477 on endothelin-1-induced renal responses in anaesthetized dogs

Abstract

Keywords

ASJC Scopus subject areas

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