Effects of NKH477 on endothelin-1-induced renal responses in anaesthetized dogs

Sunao Hara, Masayuki Tanahashi, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)-1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET-1 infusion. 3. These results demonstrate that NKH477 can counteract ET-1-induced antinatriuresis, mainly by restoring glomerular filtration.

Original languageEnglish
Pages (from-to)513-515
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Issue number7
Publication statusPublished - 2000 Jul 11
Externally publishedYes


  • Adenylate cyclase
  • Cyclic AMP
  • Dog
  • Endothelin-1
  • Glomerular filtration rate
  • Kidney
  • NKH477
  • Renal blood flow
  • Urinary Na excretion

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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