Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus

Masayoshi Nomura, Masato Tsutsui, Hiroaki Shimokawa, Naohiro Fujimoto, Yoichi Ueta, Tsuyoshi Morishita, Nobuyuki Yanagihara, Tetsuro Matsumoto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The effects of neuronal, endothelial, or inducible nitric oxide synthase gene disruption on the expression of oxytocin and vasopressin gene were examined in the hypothalamus (paraventricular, supraoptic, suprachiasmatic, and anterior commissural nuclei) and extrahypothalamus (bed nucleus of the stria terminalis). The oxytocin messenger RNA levels in the anterior commissural nucleus of neuronal nitric oxide synthase knockout mice were significantly higher than in control mice, but not in endothelial or inducible nitric oxide synthase knockout mice. In contrast, no significant effects of neuronal, endothelial, or inducible nitric oxide synthase gene disruption on oxytocin and vasopressin messenger RNA levels in the other hypothalamic and extrahypothalamic nuclei were observed. These results suggest that neuronal nitric-oxide- synthase-derived nitric oxide may be involved in the regulation of oxytocin gene expression in the anterior commissural nucleus.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalNeuroReport
Volume16
Issue number4
DOIs
Publication statusPublished - 2005 Mar 15

Keywords

  • Arginine vasopressin
  • In-situ hybridization histochemistry
  • Knockout mice
  • Nitric oxide synthase
  • Oxytocin

ASJC Scopus subject areas

  • Neuroscience(all)

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