TY - JOUR
T1 - Effects of nasal continuous positive airway pressure on awake ventilatory responses to hypoxia and hypercapnia in patients with obstructive sleep apnea
AU - Tun, Ye
AU - Hida, Wataru
AU - Okabe, Shinichi
AU - Kikuchi, Yoshihiro
AU - Kurosawa, Hajime
AU - Tabata, Masao
AU - Shirato, Kunio
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - This study was aimed to examine the short-and long-term effects of nasal continuous positive airway pressure (CPAP) on the chemosensitivity to hypoxia and hypercapnia in the patients with obstructive sleep apnea (OSA). Awake ventilatory responses to hypoxia and hypercapnia were examined in 28 patients (3 female) with moderate to severe OSA. All these tests were examined before and after 2 weeks of nasal CPAP. In 10 patients these tests were repeated after 3-6 months of nasal CPAP. All were also tested for spirometry and arterial blood gas analysis. Patients were middle-aged (48.9 ± 9.9 years) and their mean apnea-hypopnea index was 58.3 ± 20.4/hour. After 2 week of nasal CPAP, PaO2 significantly increased (77.7 ± 11.8 vs. 84.6 ± 9.8 mmHg) and PaCO2 significantly decreased (44.9 ± 3.8 vs. 42.3 ± 3.7 mmHg). The ventilatory response to hypoxia significantly decreased (0.80 ± 0.51 vs. 0.61 ± 0.51 liter/mm/%) whereas the ventilatory response to hypercapnia significantly increased after 2 weeks (1.47 ± 0.73 vs. 1.80± 0.76 liter/min/mmHg). Similar findings were also observed after 3-6 months of nasal CPAP in 10 OSA patients. Nasal CPAP treatment can alter the ventilatory responses in patients with OSA.
AB - This study was aimed to examine the short-and long-term effects of nasal continuous positive airway pressure (CPAP) on the chemosensitivity to hypoxia and hypercapnia in the patients with obstructive sleep apnea (OSA). Awake ventilatory responses to hypoxia and hypercapnia were examined in 28 patients (3 female) with moderate to severe OSA. All these tests were examined before and after 2 weeks of nasal CPAP. In 10 patients these tests were repeated after 3-6 months of nasal CPAP. All were also tested for spirometry and arterial blood gas analysis. Patients were middle-aged (48.9 ± 9.9 years) and their mean apnea-hypopnea index was 58.3 ± 20.4/hour. After 2 week of nasal CPAP, PaO2 significantly increased (77.7 ± 11.8 vs. 84.6 ± 9.8 mmHg) and PaCO2 significantly decreased (44.9 ± 3.8 vs. 42.3 ± 3.7 mmHg). The ventilatory response to hypoxia significantly decreased (0.80 ± 0.51 vs. 0.61 ± 0.51 liter/mm/%) whereas the ventilatory response to hypercapnia significantly increased after 2 weeks (1.47 ± 0.73 vs. 1.80± 0.76 liter/min/mmHg). Similar findings were also observed after 3-6 months of nasal CPAP in 10 OSA patients. Nasal CPAP treatment can alter the ventilatory responses in patients with OSA.
KW - Nasal continuous positive airway pressure
KW - Obstructive sleep apnea
KW - Ventilatory responses
UR - http://www.scopus.com/inward/record.url?scp=0034137529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034137529&partnerID=8YFLogxK
U2 - 10.1620/tjem.190.157
DO - 10.1620/tjem.190.157
M3 - Article
C2 - 10770623
AN - SCOPUS:0034137529
VL - 190
SP - 157
EP - 168
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 2
ER -