Effects of nasal continuous positive airway pressure on awake ventilatory responses to hypoxia and hypercapnia in patients with obstructive sleep apnea

Ye Tun, Wataru Hida, Shinichi Okabe, Yoshihiro Kikuchi, Hajime Kurosawa, Masao Tabata, Kunio Shirato

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23 Citations (Scopus)

Abstract

This study was aimed to examine the short-and long-term effects of nasal continuous positive airway pressure (CPAP) on the chemosensitivity to hypoxia and hypercapnia in the patients with obstructive sleep apnea (OSA). Awake ventilatory responses to hypoxia and hypercapnia were examined in 28 patients (3 female) with moderate to severe OSA. All these tests were examined before and after 2 weeks of nasal CPAP. In 10 patients these tests were repeated after 3-6 months of nasal CPAP. All were also tested for spirometry and arterial blood gas analysis. Patients were middle-aged (48.9 ± 9.9 years) and their mean apnea-hypopnea index was 58.3 ± 20.4/hour. After 2 week of nasal CPAP, PaO2 significantly increased (77.7 ± 11.8 vs. 84.6 ± 9.8 mmHg) and PaCO2 significantly decreased (44.9 ± 3.8 vs. 42.3 ± 3.7 mmHg). The ventilatory response to hypoxia significantly decreased (0.80 ± 0.51 vs. 0.61 ± 0.51 liter/mm/%) whereas the ventilatory response to hypercapnia significantly increased after 2 weeks (1.47 ± 0.73 vs. 1.80± 0.76 liter/min/mmHg). Similar findings were also observed after 3-6 months of nasal CPAP in 10 OSA patients. Nasal CPAP treatment can alter the ventilatory responses in patients with OSA.

Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalTohoku Journal of Experimental Medicine
Volume190
Issue number2
DOIs
Publication statusPublished - 2000 Feb

Keywords

  • Nasal continuous positive airway pressure
  • Obstructive sleep apnea
  • Ventilatory responses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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