Effects of muscarinic and adrenergic blockade on growth hormone secretion induced by growth hormone-releasing peptide-2 (GHRP-2) in ovariectomized ewes

Sang Gun Roh, Minoru Hirota, Mao Long He, Nobuyoshi Matsunaga, Satoshi Hidaka, Hisashi Hidari

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study was performed to investigate whether the blockade of cholinergic muscarinic and adrenergic pathways was involved in the GH- releasing effect of GH-releasing peptide-2 (GHRP-2) in ovariectomized ewes. Cholinergic muscarinic antagonist, atropine (0.2 mg/kg, iv, 15 min before GHRP-2 administration) blunted the GH secretion caused by GHRP-2 (12.5 μg/kgBW). α-Adrenergic antagonist phentolamine (15 μg/kgBW·min, infusion from -15 to 30 min) did not affect the GH response to GHRP-2, and β- adrenergic antagonist propranolol (0.25 mg/kgBW, iv, 15 min before GHRP-2 administration) did not suppress the GHRP-2-induced GH release. These results showed that cholinergic muscarinic antagonist agent, atropine, exerts an inhibitory effect on GHRP-2-induced GH secretion in ovariectomized ewes.

Original languageEnglish
Pages (from-to)861-865
Number of pages5
Journalendocrine journal
Volume44
Issue number6
DOIs
Publication statusPublished - 1997 Dec
Externally publishedYes

Keywords

  • Adrenergic receptor
  • GH
  • GH-releasing peptide-2 (GHRP-2)
  • Muscarinic receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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