Effects of muscarinic and adrenergic blockade on growth hormone secretion induced by growth hormone-releasing peptide-2 (GHRP-2) in ovariectomized ewes

Sang Gun Roh; Minoru Hirota; Mao Long He; Nobuyoshi Matsunaga; Satoshi Hidaka; Hisashi Hidari

doi:10.1507/endocrj.44.861

Effects of muscarinic and adrenergic blockade on growth hormone secretion induced by growth hormone-releasing peptide-2 (GHRP-2) in ovariectomized ewes

Sang Gun Roh, Minoru Hirota, Mao Long He, Nobuyoshi Matsunaga, Satoshi Hidaka, Hisashi Hidari

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

This study was performed to investigate whether the blockade of cholinergic muscarinic and adrenergic pathways was involved in the GH- releasing effect of GH-releasing peptide-2 (GHRP-2) in ovariectomized ewes. Cholinergic muscarinic antagonist, atropine (0.2 mg/kg, iv, 15 min before GHRP-2 administration) blunted the GH secretion caused by GHRP-2 (12.5 μg/kgBW). α-Adrenergic antagonist phentolamine (15 μg/kgBW·min, infusion from -15 to 30 min) did not affect the GH response to GHRP-2, and β- adrenergic antagonist propranolol (0.25 mg/kgBW, iv, 15 min before GHRP-2 administration) did not suppress the GHRP-2-induced GH release. These results showed that cholinergic muscarinic antagonist agent, atropine, exerts an inhibitory effect on GHRP-2-induced GH secretion in ovariectomized ewes.

Original language	English
Pages (from-to)	861-865
Number of pages	5
Journal	endocrine journal
Volume	44
Issue number	6
DOIs	https://doi.org/10.1507/endocrj.44.861
Publication status	Published - 1997 Dec
Externally published	Yes

Keywords

Adrenergic receptor
GH
GH-releasing peptide-2 (GHRP-2)
Muscarinic receptor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1507/endocrj.44.861

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title = "Effects of muscarinic and adrenergic blockade on growth hormone secretion induced by growth hormone-releasing peptide-2 (GHRP-2) in ovariectomized ewes",

abstract = "This study was performed to investigate whether the blockade of cholinergic muscarinic and adrenergic pathways was involved in the GH- releasing effect of GH-releasing peptide-2 (GHRP-2) in ovariectomized ewes. Cholinergic muscarinic antagonist, atropine (0.2 mg/kg, iv, 15 min before GHRP-2 administration) blunted the GH secretion caused by GHRP-2 (12.5 μg/kgBW). α-Adrenergic antagonist phentolamine (15 μg/kgBW·min, infusion from -15 to 30 min) did not affect the GH response to GHRP-2, and β- adrenergic antagonist propranolol (0.25 mg/kgBW, iv, 15 min before GHRP-2 administration) did not suppress the GHRP-2-induced GH release. These results showed that cholinergic muscarinic antagonist agent, atropine, exerts an inhibitory effect on GHRP-2-induced GH secretion in ovariectomized ewes.",

keywords = "Adrenergic receptor, GH, GH-releasing peptide-2 (GHRP-2), Muscarinic receptor",

author = "Roh, {Sang Gun} and Minoru Hirota and He, {Mao Long} and Nobuyoshi Matsunaga and Satoshi Hidaka and Hisashi Hidari",

year = "1997",

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doi = "10.1507/endocrj.44.861",

language = "English",

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AU - Hirota, Minoru

AU - He, Mao Long

AU - Matsunaga, Nobuyoshi

AU - Hidaka, Satoshi

AU - Hidari, Hisashi

PY - 1997/12

Y1 - 1997/12

N2 - This study was performed to investigate whether the blockade of cholinergic muscarinic and adrenergic pathways was involved in the GH- releasing effect of GH-releasing peptide-2 (GHRP-2) in ovariectomized ewes. Cholinergic muscarinic antagonist, atropine (0.2 mg/kg, iv, 15 min before GHRP-2 administration) blunted the GH secretion caused by GHRP-2 (12.5 μg/kgBW). α-Adrenergic antagonist phentolamine (15 μg/kgBW·min, infusion from -15 to 30 min) did not affect the GH response to GHRP-2, and β- adrenergic antagonist propranolol (0.25 mg/kgBW, iv, 15 min before GHRP-2 administration) did not suppress the GHRP-2-induced GH release. These results showed that cholinergic muscarinic antagonist agent, atropine, exerts an inhibitory effect on GHRP-2-induced GH secretion in ovariectomized ewes.

AB - This study was performed to investigate whether the blockade of cholinergic muscarinic and adrenergic pathways was involved in the GH- releasing effect of GH-releasing peptide-2 (GHRP-2) in ovariectomized ewes. Cholinergic muscarinic antagonist, atropine (0.2 mg/kg, iv, 15 min before GHRP-2 administration) blunted the GH secretion caused by GHRP-2 (12.5 μg/kgBW). α-Adrenergic antagonist phentolamine (15 μg/kgBW·min, infusion from -15 to 30 min) did not affect the GH response to GHRP-2, and β- adrenergic antagonist propranolol (0.25 mg/kgBW, iv, 15 min before GHRP-2 administration) did not suppress the GHRP-2-induced GH release. These results showed that cholinergic muscarinic antagonist agent, atropine, exerts an inhibitory effect on GHRP-2-induced GH secretion in ovariectomized ewes.

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KW - Muscarinic receptor

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Effects of muscarinic and adrenergic blockade on growth hormone secretion induced by growth hormone-releasing peptide-2 (GHRP-2) in ovariectomized ewes

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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