Effects of muramyl dipeptide on osteoclast formation induced by LPS, IL-1 and TNF-α in mouse culture system

S. Yang, N. Takahashi, M. Takahashi, Haruhiko Takada, K. Furusawa, N. Udagawa

Research output: Contribution to journalArticlepeer-review

Abstract

Muramyl dipeptide (MDP), the essential structure responsible for the immunoadjuvant activity of peptidoglycan, exists in Gram-positive and -negative bacterial walls. MDP synergistically enhances osteoclast formation induced by LPS, IL-1 and TNF-α through RANKL expression in osteoblasts. Nod2-mediated signals appear to be involved in the MDP-induced RANKL expression in osteoblasts.

Original languageEnglish
Pages (from-to)211-212
Number of pages2
JournalInternational Congress Series
Volume1284
DOIs
Publication statusPublished - 2005 Sep 1

Keywords

  • IL-1
  • LPS
  • MDP
  • Nod2
  • RANKL
  • TNF-α

ASJC Scopus subject areas

  • Medicine(all)

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