Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans

Yoshihiro Kojima, Toshiyuki Kimura, Kiyotaka Nakagawa, Akira Asai, Keiji Hasumi, Shinichi Oikawa, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume47
Issue number2
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • 1-deoxynojirimycin
  • Mulberry leaf extract
  • Serum lipid profile
  • Serum triglyceride

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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