Effects of lung volume reduction surgery for emphysema on oxygen cost of breathing

Tetsuro Takayama, Chiyohiko Shindoh, Yoshimochi Kurokawa, Wataru Hida, Hajime Kurosawa, Hiromasa Ogawa, Susumu Satomi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Background: Patients with severe pulmonary emphysema have a greatly increased oxygen cost of breathing (O2 cost), and this is the cause of serious malnutrition, or respiratory cachexia, in such patients. Study objectives: To clarify the effect of lung volume reduction surgery (LVRS) on respiratory function and the nutritional state of these patients through a reduction in the O2 cost of the respiratory, muscles. Design: Prospective cohort study. Setting, patients, and interventions: Twenty-three patients who underwent LVRS in Tohoku University Hospital. Measurements: Pulmonary function and O2 cost were measured perioperatively by utilizing a method of continuous dead space. In addition, we calculated the proportion of oxygen consumption (V̇O2) of respiratory muscles to total V̇O2 (%V̇O2resp) from the measured energy expenditure and the predicted values. Results: FEV1 and arterial oxygen pressure increased after surgery while lung volume and dyspnea decreased (p < 0.01), and O2 cost was also reduced from 0.044 to 0.026 log(mL/min)/(L/min) [p < 0.001]. Moreover, the change in O2 cost had a strong negative correlation with that of FEW1 (r = -0.70, p < 0.001), and a moderate positive correlation with that of the ratio of residual volume to total lung capacity (r = 0.54, p < 0.01). %V̇O2resp was 23.1% at rest and 55.5% at maximal ventilation. LVRS reduced %V̇O2resp at maximal ventilation to 49.0% (p < 0.05), but %V̇O2resp at rest did not decrease after surgery. Conclusions: LVRS reduces energy expenditure of respiratory muscles especially during exercise by decreasing small airway obstruction and hyperinflated lung volume. This may reverse the malnourished state in end-stage emphysema.

Original languageEnglish
Pages (from-to)1847-1852
Number of pages6
JournalChest
Volume123
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1

Keywords

  • Lung volume reduction surgery
  • Oxygen cost of breathing
  • Pulmonary emphysema
  • Respiratory muscles

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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