Effects of local osteoprotegerin gene transfection on orthodontic root resorption during retention: An in vivo micro-CT analysis

N. Zhao, Y. Liu, H. Kanzaki, W. Liang, J. Ni, J. Lin

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Objectives- External root resorption (ERR) is a serious complication of orthodontic treatment. Aim of this study was to evaluate the effects of local osteoprotegerin (OPG) gene transfection on ERR during retention. Material and Methods- Eighteen 6-week-old male Wistar rats were divided into three groups. All the rats were subjected to 2weeks of orthodontic tooth movement followed by a 2-week retention period. During retention, the three groups of rats received local OPG gene transfection (OPG transfection group, n=6), mock vector transfection (mock group, n=6), or no injections (control group, n=6). ERR of all three groups was evaluated with in vivo micro-CT analysis at three different time points: baseline, the last day of orthodontic tooth movement, and the last day of retention. Results- In the OPG transfection group, there was no significant difference between ERR at the baseline and ERR on the last day of retention. By the last day of retention, the repair ratio of ERR in the OPG transfection group was statistically higher in relation to the repair ratio of the other groups (p<0.001). Conclusion- The results indicated that local OPG gene transfection significantly enhanced the repair of ERR during retention. Local OPG gene transfection might therefore be a useful tool for ERR repair during retention.

Original languageEnglish
Pages (from-to)10-20
Number of pages11
JournalOrthodontics and Craniofacial Research
Volume15
Issue number1
DOIs
Publication statusPublished - 2012 Feb
Externally publishedYes

Keywords

  • Micro-CT
  • Orthodontic tooth movement
  • Osteoprotegerin
  • Root resorption

ASJC Scopus subject areas

  • Orthodontics
  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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