Effects of inhaled beclomethasone dipropionate on serum IgE levels and clinical symptoms in atopic asthma

T. Ohrui, T. Funayama, K. Sekizawa, M. Yamaya, H. Sasaki

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Background: A high serum immunoglobulin (Ig)E level is considered a potent predictor for the development of asthma and IgE is targeted for treatment of asthma. Although inhaled corticosteroids are well established in the treatment of asthma, the effects of inhaled corticosteroids on serum IgE levels in asthma remain uncertain. Methods: We therefore examined asthma symptoms, concentrations of total serum IgE and specific IgE antibodies to selected allergens, blood eosinophil counts and lung functions before and 3 months after treatment with either inhaled beclomethasone dipropionate (BDP; 800 μg/day) (n = 7) or inhaled β2-agonists alone (n = 7) in patients with atopic asthma in a randomized, double-blind, parallel-group controlled trial. Results: Inhaled BDP significantly improved asthma symptom scores and forced expiratory volume in 1 s, and decreased blood eosinophil counts, total serum IgE levels and specific IgE antibodies to house dust mite and cedar. Decreases in total serum IgE significantly correlated with an improvement in asthma symptom scores. In contrast, none of parameters altered in patients with atopic asthma treated with inhaled β2-agonists alone. Conclusions: Inhaled corticosteroids may improve the subsequent clinical course of atopic asthma in association with a reduction of serum IgE levels.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalClinical and Experimental Allergy
Volume29
Issue number3
DOIs
Publication statusPublished - 1999

Keywords

  • Allergic reaction
  • Immunoglobulins
  • Inflammation
  • Skin-prick test

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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