TY - JOUR
T1 - Effects of Indomethacin on Plasma Renin Activity, Plasma Aldosterone Concentration, Urinary Prostaglandin E Excretion and Blood Pressure in Patients with Essential Hypertension
AU - Yasujima, Minoru
AU - Abe, Keishi
AU - Chiba, Satoru
AU - Sato, Makito
AU - Irokawa, Nobuo
AU - Imai, Yutaka
AU - Saito, Keitaro
AU - Sakurai, Yutaka
AU - Ito, Toru
AU - Ritsu, Kancho
AU - Haruyama, Toshiaki
AU - Otsuka, Yoichi
AU - Yoshinaga, Kaoru
PY - 1979
Y1 - 1979
N2 - Yasujima, M., Abe, K., Chiba, S., Sato, M., Irokawa, N., Imai, Y., Saito, K., Sakurai, Y., Ito, T., Ritsu, K., Haruyama, T., Otsuka, Y. and Yoshinaga, K. Effects of Indomethacin on Plasma Renin Activity, Plasma Aldosterone Concentration, Urinary Prostaglandin E Excretion and Blood Pressure in Patients with Essential Hypertension. Tohoku J. exp. Med., 1979, 128 (1), p.31-37 - To investigate the interrelationship between the renin-angiotensin-aldosterone system and prostaglandin system, plasma renin activity, plasma aldosterone concentration, urinary sodium excretion, urinary prostaglandin E excretion and blood pressure were determined before and after administration of indomethacin, a prostaglandin synthetase inhibitor, during sodium depletion with furosemide administration and low sodium diets in 11 patients with essential hypertension. With the addition of indomethacin, plasma renin activity decreased from 52.9±8.6 ng/ml to 8.5±1.3 ng/ml, plasma aldosterone concentration from 20.4±3.7 ng/100 ml to 5.4±1.3 ng/100 ml, and urinary prostaglandin E excretion from 330.1±58.8 ng/day to 168.8±32.8 ng/day. Significant positive correlation was found between the change of plasma renin activity and that of urinary prostaglandin E excretion (τ=0.73, p<0.01). The addition of indomethacin did not produce any significant change in urinary sodium excretion (from 78.0± 10.6 mEq/day to 61.2±11.6 mEq/day); whereas indomethacin administration diminished the hypotensive effects of furosemide administration and low sodium diets. The present results show that renal prostaglandin E may be one of the regulators of renal renin release, and that the use of indomethacin, an antiinflammatory drug frequently prescribed in recent years, may diminish the hypotensive effects of furosemide and other diuretics. - indomethacin; sodium depletion; renal prostaglandin system; renin-angiotensin-aldosterone system; essential hypertension.
AB - Yasujima, M., Abe, K., Chiba, S., Sato, M., Irokawa, N., Imai, Y., Saito, K., Sakurai, Y., Ito, T., Ritsu, K., Haruyama, T., Otsuka, Y. and Yoshinaga, K. Effects of Indomethacin on Plasma Renin Activity, Plasma Aldosterone Concentration, Urinary Prostaglandin E Excretion and Blood Pressure in Patients with Essential Hypertension. Tohoku J. exp. Med., 1979, 128 (1), p.31-37 - To investigate the interrelationship between the renin-angiotensin-aldosterone system and prostaglandin system, plasma renin activity, plasma aldosterone concentration, urinary sodium excretion, urinary prostaglandin E excretion and blood pressure were determined before and after administration of indomethacin, a prostaglandin synthetase inhibitor, during sodium depletion with furosemide administration and low sodium diets in 11 patients with essential hypertension. With the addition of indomethacin, plasma renin activity decreased from 52.9±8.6 ng/ml to 8.5±1.3 ng/ml, plasma aldosterone concentration from 20.4±3.7 ng/100 ml to 5.4±1.3 ng/100 ml, and urinary prostaglandin E excretion from 330.1±58.8 ng/day to 168.8±32.8 ng/day. Significant positive correlation was found between the change of plasma renin activity and that of urinary prostaglandin E excretion (τ=0.73, p<0.01). The addition of indomethacin did not produce any significant change in urinary sodium excretion (from 78.0± 10.6 mEq/day to 61.2±11.6 mEq/day); whereas indomethacin administration diminished the hypotensive effects of furosemide administration and low sodium diets. The present results show that renal prostaglandin E may be one of the regulators of renal renin release, and that the use of indomethacin, an antiinflammatory drug frequently prescribed in recent years, may diminish the hypotensive effects of furosemide and other diuretics. - indomethacin; sodium depletion; renal prostaglandin system; renin-angiotensin-aldosterone system; essential hypertension.
UR - http://www.scopus.com/inward/record.url?scp=0018756927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018756927&partnerID=8YFLogxK
U2 - 10.1620/tjem.128.31
DO - 10.1620/tjem.128.31
M3 - Article
C2 - 452004
AN - SCOPUS:0018756927
SN - 0040-8727
VL - 128
SP - 31
EP - 37
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
IS - 1
ER -