Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats

C. Ito, K. Onodera, T. Watanabe, M. Sato

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

In this study, effects of histamine (HA) agents on methamphetamine (METH)-induced stereotyped behavior and behavioral sensitization were examined in rats. Pretreatment with a precursor of HA, L-histidine (750 mg/kg), significantly inhibited the METH (3 mg/kg)-induced stereotyped behavior, whereas pretreatment with an inhibitor of HA synthesis, α-fluoromethylhistidine (FMH) (100 mg/kg), an H1 antagonist pyrilamine (5 mg/kg) or an H2 antagonist zolantidine (5 mg/kg) enhanced it. The inhibitory effect of L-histidine on METH-induced stereotyped behavior was significantly blocked by coadministration of pyrilamine and zolantidine, indicating that the effect is mediated through H1 and H2 receptors. Moreover, chronic treatment with METH (3 mg/kg) significantly enhanced stereotyped behavior at the rechallenge with METH (1 mg/kg). Chronic treatment with L-histidine (750 mg/kg) plus METH inhibited the METH-induced argumentation of stereotyped behavior, while that with FMH (100 mg/kg), pyrilamine (5 mg/kg) or zolantidine (5 mg/kg) potentiated it. These findings suggest that the HA neuron system has an inhibitory role in METH-induced stereotyped behavior and behavioral sensitization.

Original languageEnglish
Pages (from-to)362-367
Number of pages6
JournalPsychopharmacology
Volume130
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • L-histidine
  • behavioral sensitization
  • histamine
  • methamphetamine
  • pyrilamine
  • stereotyped behavior
  • zolantidine
  • α-fluoromethylhistidine

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats'. Together they form a unique fingerprint.

Cite this