Effects of highly purified structured lipids containing medium-chain fatty acids and linoleic acid on lipid profiles in rats

Jun Ichi Nagata, Michio Kasai, Souichiro Watanabe, Ikuo Ikeda, Morio Saito

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The purpose of this study is to examine the effects of highly purified structured lipids on serum and liver lipid profiles in rats. We also investigated in vitro hydrolysis of lipid emulsions by porcine pancreas. Hydrolysis rates of medium chain (M)-linoleic (L)-medium chain (M) types were 2 to 3 times higher than those of L-M-L types. The diet containing structured lipids or corn oil was administered to rats for 4 weeks. There were no significant differences in growth and food efficiency. Serum cholesterol levels were significantly lower (P<0.05) in the 2-octanoyl-1,3-dilinoleoyl-glycerol, 2-linoleoyl-1,3-didecanoyl-glycerol, and 2-decanoyl-1,3-dilinoleoyl-glycerol groups than in the corn-oil group. Serum triglyceride levels were significantly lower (P < 0.05) in rats fed L-M-L types than those in the other groups. Serum non-esterified fatty acid (NEFA) and β-hydroxybutylate levels were significantly higher (P < 0.01) in rats fed M-L-M types than those of the other groups. These results indicate that the feeding of highly purified L-M-L types could effectively improve serum and liver lipid profiles and that M-L-M types may be a preferable substrate for the pancreas and contribute to energy supply in rats.

Original languageEnglish
Pages (from-to)1937-1943
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume67
Issue number9
DOIs
Publication statusPublished - 2003 Sep
Externally publishedYes

Keywords

  • Lipid profiles
  • Medium-chain fatty acid
  • Rats
  • Structured lipids

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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