Effects of heat-killed lactobacillus pentosus S-PT84 on postprandial hypertriacylglycerolemia in rats

Yongwei Zhou, Nao Inoue, Ran Ozawa, Toshihiro Maekawa, Takayuki Izumo, Yoshinori Kitagawa, Yoshinobu Kiso, Hiroshi Shibata, Ikuo Ikeda

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11 Citations (Scopus)


The effect of Lactobacillus pentosus strain S-PT84 (S-PT84) on postprandial hypertriacylglycerolemia was investigated in rats. S-PT84 dose-dependently inhibited the hydrolysis of triacylglycerols by pancreatic lipase in vitro. Intragastric administration of S-PT84 significantly reduced the lymphatic recovery of 3H-trioleoylglycerol up to 8 h. The oral administration of a fat emulsion, with or without S-PT84, resulted in the concentration of plasma triacylglycerol 2 h and 3 h after administration being significantly lower in the S-PT84 group than in the group without S-PT84 (control group). These results suggest that S-PT84 alleviated postprandial hypertriacylglycerolemia by delaying triacylglycerol absorption in the intestine through the inhibition of pancreatic lipase.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number3
Publication statusPublished - 2013


  • Lactobacillus pentosus S-PT84
  • Pancreatic lipase
  • Postprandial hypertriacylglycerolemia
  • Rat

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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