TY - JOUR
T1 - Effects of green tea polyphenols on iodide-induced autoimmune thyroiditis in nonobese diabetic mice
AU - Hoshikawa, Saeko
AU - Nakagawa, Yoshinori
AU - Ozaki, Hiroshi
AU - Takahashi, Yurie
AU - Ito, Sadayoshi
AU - Yoshida, Katsumi
AU - Mori, Kouki
PY - 2013
Y1 - 2013
N2 - Because green tea polyphenols (GTPs) possess anti-inflammatory properties and are effective in inhibiting autoimmune diseases in experimental settings, we examined whether GTPs prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were given 0.05% iodide water or iodide water supplemented with 0.2% GTPs for 8 weeks. GTPs administration led to an enhanced production of interleukin-10 by concanavalin A-stimulated splenocytes but did not interfere with thyroiditis development. Serum thyroxine levels were not influenced by GTPs. Our data suggest that administration of GTPs may not be an effective strategy for the prevention of HT.
AB - Because green tea polyphenols (GTPs) possess anti-inflammatory properties and are effective in inhibiting autoimmune diseases in experimental settings, we examined whether GTPs prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were given 0.05% iodide water or iodide water supplemented with 0.2% GTPs for 8 weeks. GTPs administration led to an enhanced production of interleukin-10 by concanavalin A-stimulated splenocytes but did not interfere with thyroiditis development. Serum thyroxine levels were not influenced by GTPs. Our data suggest that administration of GTPs may not be an effective strategy for the prevention of HT.
KW - Green tea polyphenols
KW - Hashimoto's thyroiditis
KW - Iodide
KW - Nonobese diabetic mouse
UR - http://www.scopus.com/inward/record.url?scp=84874896982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874896982&partnerID=8YFLogxK
U2 - 10.3109/08820139.2012.753611
DO - 10.3109/08820139.2012.753611
M3 - Article
C2 - 23461615
AN - SCOPUS:84874896982
VL - 42
SP - 235
EP - 246
JO - Immunological Investigations
JF - Immunological Investigations
SN - 0882-0139
IS - 3
ER -
