Effects of green tea polyphenols on iodide-induced autoimmune thyroiditis in nonobese diabetic mice

Saeko Hoshikawa, Yoshinori Nakagawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito, Katsumi Yoshida, Kouki Mori

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Because green tea polyphenols (GTPs) possess anti-inflammatory properties and are effective in inhibiting autoimmune diseases in experimental settings, we examined whether GTPs prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis (HT). Mice were given 0.05% iodide water or iodide water supplemented with 0.2% GTPs for 8 weeks. GTPs administration led to an enhanced production of interleukin-10 by concanavalin A-stimulated splenocytes but did not interfere with thyroiditis development. Serum thyroxine levels were not influenced by GTPs. Our data suggest that administration of GTPs may not be an effective strategy for the prevention of HT.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalImmunological Investigations
Volume42
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Green tea polyphenols
  • Hashimoto's thyroiditis
  • Iodide
  • Nonobese diabetic mouse

ASJC Scopus subject areas

  • Immunology

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