Effects of gemfibrozil administration on very low density lipoprotein receptor mRNA levels in rabbits

Naoki Matsuoka, Hisato Jingami, Hiroaki Masuzaki, Megumi Mizuno, Shigeo Nakaishi, Junko Suga, Tokuji Tanaka, Tokuo Yamamoto, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

To elucidate the regulation of very low density lipoprotein (VLDL) receptor gene expression, we administered to rabbits for 14 days gemfibrozil, a fibric acid derivative and a lipid lowering drug that is also included among peroxisome proliferators. VLDL receptor mRNA levels were examined by Northern blot analysis. The VLDL receptor mRNA levels in retroperitoneal adipose tissue and in gastrocnemius muscle were increased 6.9-fold and 3.7-fold; respectively, with gemfibrozil treatment, but no marked changes-were observed in the heart, the organ in which VLDL receptor is most highly expressed. In the liver, VLDL receptor mRNA was not detected either before or after gemfibrozil administration. Lipoprotein lipase (LPL) and long-chain acyl coenzyme A synthetase (ACS) mRNA levels were also increased in parallel in adipose tissue. The enhanced expression of VLDL receptor mRNA may contribute to the increase of triglyceride-rich lipoprotein catabolism in peripheral tissues such as adipose tissue and muscles.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalAtherosclerosis
Volume126
Issue number2
DOIs
Publication statusPublished - 1996 Oct 25

Keywords

  • Gemfibrozil
  • Rabbit
  • VLDL receptor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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