Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: Dietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may be effective in prevention of AHL due to their anti-inflammatory and tissue-protective functions. Age-related changes in the hearing function of wild-type and Fat-1 transgenic mice derived from the C57BL/6N strain, which can convert omega-6 PUFAs to n-3 PUFAs and consequently produce enriched endogenous n-3 PUFAs, were investigated to test the efficacy of n-3 PUFAs for AHL prevention. Results: At 2 months, the baseline auditory brainstem response (ABR) thresholds were the same in Fat-1 and wild-type mice at 8-16 kHz but were significantly higher in Fat-1 mice at 4 and 32 kHz. In contrast, the ABR thresholds of Fat-1 mice were significantly lower at 10 months. Moreover, the ABR thresholds of Fat-1 mice at low-middle frequencies were significantly lower at 13 months (12 kHz). Body weights were significantly reduced in Fat-1 mice at 13 months, but not at 2, 10, and 16-17 months. In conclusion, enriched endogenous n-3 PUFAs produced due to the expression of the Fat-1 transgene partially alleviated AHL in male C57BL/6N mice.

Original languageEnglish
Article number768
JournalBMC Research Notes
Volume12
Issue number1
DOIs
Publication statusPublished - 2019 Nov 26

Keywords

  • Age-related hearing loss
  • C57BL/6 mouse
  • Cochlea
  • Omega-3 (n-3) fatty acids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice'. Together they form a unique fingerprint.

Cite this