Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats

Li San Zhang, Zhong Chen, Yu Wen Huang, Wei Wei Hu, Er Qing Wei, Kazuhiko Yanai

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

This study was performed to investigate whether or not endogenous histamine can protect seizure development of pentylenetetrazole (PTZ)-induced kindling in rats. An intracerebroventricular (i.c.v.) injection with clobenpropit (5 and 10 μg), a representative H3-antagonist, significantly prolonged the onset of kindling and inhibited the seizure stages in a dose-dependent manner. Its action was significantly reversed by both immepip (2 μg, i.c.v.), an H3-agonist, and α-fluoromethylhistidine (α-FMH, 10 μg, i.c.v.), a selective histidine decarboxylase inhibitor. α-FMH (20 μg, i.c.v.) and pyrilamine (1 and 5 mg/kg i.p.), a classical H1-antagonist, markedly augmented the severity of seizure development of PTZ-induced kindling. Therefore, these results indicate that brain endogenous histamine plays a certain protective role on seizure development of PTZ-induced kindling in rats, and that its protective roles are mediated by H1-receptors.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalPharmacology
Volume69
Issue number1
DOIs
Publication statusPublished - 2003 Aug 11

Keywords

  • Clobenpropit
  • Endogenous histamine
  • Immepip
  • Pentylenetetrazole kindling
  • α-Fluoromethylhistidine

ASJC Scopus subject areas

  • Pharmacology

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