Effects of Elastic Loading and Exercise on Pulmonary Gas Exchange in Dogs

Tatsuya Chonan, Wataru Hida, Yoshihiro Kikuchi, Chiyohiko Shindoh, Osamu Taguchi, Hiroshi Miki, Tamotsu Takishima

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We assessed the effects of negative intrathoracic pressure induced by inspiratory elastic loading on pulmonary, gas exchange with and without electrically induced hindlimb exercise in 8 normal, anesthetized dogs. Two elastic loads (EL) were used; one of 81 and one of 140cmH2O/liter. These are equivalent to doubling and tripling the normal elastance of the dog's respiratory system, respectively. Elastic loading decreased ventilation and caused hypoxemia and hypercapnia, but it did not affect systemic arterial pressure or heart rate. During exercise, increase in ventilation was limited, whereas increase in cardiac output was not affected by elastic loading. Alveolar-arterial O2 tension difference (A-aDO2) was not changed significantly by exercise alone. However, elastic loading accompanied by exercise increased A-aDO2. Although comparable end-inspiratory pleural pressure was achieved with large EL (-29±2cmH2O, mean±SE) and small EL with exercise (-30± 2cmH2O), the latter increased A-aDO2 whereas the former did not. Large negative intrapleural pressure combined with increased cardiac output may have caused transient interstitial edema.

Original languageEnglish
Pages (from-to)157-167
Number of pages11
JournalTohoku Journal of Experimental Medicine
Issue number2
Publication statusPublished - 1991


  • alveolar-arterial oxygen tension difference
  • exercise
  • loaded breathing
  • pulmonary gas exchange

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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