Effects of dietary uridine 5′-monophosphate on immune responses in newborn calves

T. Mashiko, S. Nagafuchi, M. Kanbe, Y. Obara, Y. Hagawa, T. Takahashi, K. Katoh

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

When compared with normal milk, bovine colostrum contains a large amount of uridine 5′-monophosphate (UMP) and its derivatives. In the present study, we carried out 2 experiments to determine the effects of dietary UMP (2 g/d) on the immune status of newborn calves. In Exp. 1, newborn Holstein bull calves were fed milk replacer alone (control group) or milk replacer supplemented with UMP (UMP group) from d 4 to 10 after birth. The increase in interferon-γ concentration by peripheral blood mononuclear cells (PBMC) on d 24 tended to be greater in the UMP group than in the control group (P = 0.06). The UMP concentration of the ileal mucosa was greater in the UMP group than in the control group (P < 0.05), although there was no difference between groups in the jejunal mucosa. In Exp. 2, newborn Holstein bull calves were fed milk replacer alone (control group) or milk replacer supplemented with UMP (UMP group) from d 4 to 56 after birth. The proliferation of PBMC was greater in the UMP group than in the control group on d 14, 28, and 42 (P < 0.01). The increase in interferon-γ concentration by PBMC was greater in the UMP group than in the control group on d 28 and 42 (P < 0.05). From these results, we concluded that dietary UMP affected the immune responses of newborn calves.

Original languageEnglish
Pages (from-to)1042-1047
Number of pages6
JournalJournal of animal science
Volume87
Issue number3
DOIs
Publication statusPublished - 2009 Mar
Externally publishedYes

Keywords

  • Interferon-γ
  • Mucosal immunoglobulin A
  • Peripheral blood mononuclear cell proliferation
  • Uridine 5′-monophosphate

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

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