Effects of dietary protein and fat on linoleic and α-linolenic acid metabolism and prostacyclin production in stroke-prone spontaneous hypertensive rats

Akira Ikeda, Kosaburo Wakamatsu, Takehiro Umeda, Satoko Shikada, Ikuo Ikeda, Katsumi Imaizumi, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The effects of dietary proteins (casein or soybean protein) and fats (perilla oil high in α-linolenic acid or safflower oil high in linoleic acid) on the fatty acid composition of liver microsomes and the aortic prostacyclin production were studied in stroke-prone spontaneous hypertensive rats. The stimulating effects of casein compared to soybean protein on linoleic acid and α-linolenic acid metabolism and prostacyclin production were confirmed in this rat model. The ratio of (20:3n-6 + 20:4n-6)/18:2n-6, the linoleic acid desaturation index, of liver microsomes was reflected in that of aorta. In addition, there was a highly positive correlation between the linoleic acid desaturation index of phosphatidylcholine and the prostacyclin production of the aorta. Thus, the results of the present study indicated a significant role of dietary protein in the regulation of polyunsaturated fatty acids and hence, the eicosanoid production. The data showed a possible preferable effect of casein in relation to soybean protein.

Original languageEnglish
Pages (from-to)248-255
Number of pages8
JournalThe Journal of Nutritional Biochemistry
Volume5
Issue number5
DOIs
Publication statusPublished - 1994 Jan 1
Externally publishedYes

Keywords

  • SHR-SP
  • casein
  • linoleic acid
  • prostacyclin
  • soybean protein
  • α-linolenic acid

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

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