Abstract
The effects of dietary proteins (casein or soybean protein) and fats (perilla oil high in α-linolenic acid or safflower oil high in linoleic acid) on the fatty acid composition of liver microsomes and the aortic prostacyclin production were studied in stroke-prone spontaneous hypertensive rats. The stimulating effects of casein compared to soybean protein on linoleic acid and α-linolenic acid metabolism and prostacyclin production were confirmed in this rat model. The ratio of (20:3n-6 + 20:4n-6)/18:2n-6, the linoleic acid desaturation index, of liver microsomes was reflected in that of aorta. In addition, there was a highly positive correlation between the linoleic acid desaturation index of phosphatidylcholine and the prostacyclin production of the aorta. Thus, the results of the present study indicated a significant role of dietary protein in the regulation of polyunsaturated fatty acids and hence, the eicosanoid production. The data showed a possible preferable effect of casein in relation to soybean protein.
| Original language | English |
|---|---|
| Pages (from-to) | 248-255 |
| Number of pages | 8 |
| Journal | The Journal of Nutritional Biochemistry |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1994 Jan 1 |
| Externally published | Yes |
Keywords
- SHR-SP
- casein
- linoleic acid
- prostacyclin
- soybean protein
- α-linolenic acid
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Biology
- Nutrition and Dietetics
- Clinical Biochemistry
