TY - JOUR
T1 - Effects of dietary fats and curcumin on IgE-mediated degranulation of intestinal mast cells in brown norway rats
AU - Ju, Hyang Ran
AU - Wu, Hung Ying
AU - Nishizono, Shoko
AU - Sakono, Masanobu
AU - Ikeda, Ikuo
AU - Svgano, Michihiro
AU - Imaizumi, Katsumi
N1 - Funding Information:
Acknowledgments. This research was supported by Special Coordination Funds for Promoting Science and Technology (Joint Research Utilizing Scientific and Technological Potential) of the Japanese Government, and The Skylark Food Science Institute.
PY - 1996/1
Y1 - 1996/1
N2 - Brown Norway rats were primed intraperitoneally) with β-lactoglobulin for 3wk to induce reaginic antibody, during which time they were fed diets containing 10% each of coconut oil (CO), high oleic safflower oil, safflower oil (SO), or fish oil, then they were challenged for 3h orally with the antigen. The dietary SO, compared to other dietary fats, resulted in lower circulatory release of rat chymaseII (RChyII), an indicator of degranulation of mucosal mast cells in the intestine, in response to the antigen. Addition of 0.5% curcumin to the CO or SO diet lowered the release. The SO diet, compared to CO diet, tended to increase the concentration of reaginic antibody, but the influence of curcumin addition was not prominent. These results indicate that dietary ingredients differently influence the synthesis of immunoglobulin E and degranulation of mast cells.
AB - Brown Norway rats were primed intraperitoneally) with β-lactoglobulin for 3wk to induce reaginic antibody, during which time they were fed diets containing 10% each of coconut oil (CO), high oleic safflower oil, safflower oil (SO), or fish oil, then they were challenged for 3h orally with the antigen. The dietary SO, compared to other dietary fats, resulted in lower circulatory release of rat chymaseII (RChyII), an indicator of degranulation of mucosal mast cells in the intestine, in response to the antigen. Addition of 0.5% curcumin to the CO or SO diet lowered the release. The SO diet, compared to CO diet, tended to increase the concentration of reaginic antibody, but the influence of curcumin addition was not prominent. These results indicate that dietary ingredients differently influence the synthesis of immunoglobulin E and degranulation of mast cells.
KW - Curcumin
KW - IgE
KW - Inflammatory reaction
KW - Linoleic acid
KW - Mast cell degranulation
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U2 - 10.1271/bbb.60.1856
DO - 10.1271/bbb.60.1856
M3 - Article
C2 - 8987863
AN - SCOPUS:0030293947
VL - 60
SP - 1856
EP - 1860
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 11
ER -