Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles

Shin Ichi Izumi; Akio Tsubahara; Naoichi Chino; Kiyoshi Mineo

doi:10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5

Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles

Shin Ichi Izumi, Akio Tsubahara, Naoichi Chino, Kiyoshi Mineo

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

To examine whether a decrease in cytosolic Ca²⁺ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca²⁺ has a specific role in generating fibrillations.

Original language	English
Pages (from-to)	1797-1799
Number of pages	3
Journal	Muscle and Nerve
Volume	21
Issue number	12
DOIs	https://doi.org/10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5
Publication status	Published - 1998 Dec 10
Externally published	Yes

Keywords

Calcium ion
Dantrolene sodium
Denervation
Electromyography
Fibrillation potential

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

Access to Document

10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5

Cite this

@article{4f5d0c37f18f4619af4e46144d189358,

title = "Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles",

abstract = "To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.",

keywords = "Calcium ion, Dantrolene sodium, Denervation, Electromyography, Fibrillation potential",

author = "Izumi, {Shin Ichi} and Akio Tsubahara and Naoichi Chino and Kiyoshi Mineo",

year = "1998",

month = dec,

day = "10",

doi = "10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5",

language = "English",

volume = "21",

pages = "1797--1799",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley and Sons Inc.",

number = "12",

}

TY - JOUR

T1 - Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles

AU - Izumi, Shin Ichi

AU - Tsubahara, Akio

AU - Chino, Naoichi

AU - Mineo, Kiyoshi

PY - 1998/12/10

Y1 - 1998/12/10

N2 - To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.

AB - To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.

KW - Calcium ion

KW - Dantrolene sodium

KW - Denervation

KW - Electromyography

KW - Fibrillation potential

UR - http://www.scopus.com/inward/record.url?scp=0031787574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031787574&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5

DO - 10.1002/(SICI)1097-4598(199812)21:12<1797::AID-MUS28>3.0.CO;2-5

M3 - Article

C2 - 9843088

AN - SCOPUS:0031787574

VL - 21

SP - 1797

EP - 1799

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 12

ER -

Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this