Abstract
To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.
Original language | English |
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Pages (from-to) | 1797-1799 |
Number of pages | 3 |
Journal | Muscle and Nerve |
Volume | 21 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1998 Dec 10 |
Externally published | Yes |
Keywords
- Calcium ion
- Dantrolene sodium
- Denervation
- Electromyography
- Fibrillation potential
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)