Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles

Shin Ichi Izumi, Akio Tsubahara, Naoichi Chino, Kiyoshi Mineo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.

Original languageEnglish
Pages (from-to)1797-1799
Number of pages3
JournalMuscle and Nerve
Volume21
Issue number12
DOIs
Publication statusPublished - 1998 Dec 10
Externally publishedYes

Keywords

  • Calcium ion
  • Dantrolene sodium
  • Denervation
  • Electromyography
  • Fibrillation potential

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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