Effects of combination chemoradiotherapy with daily low-dose CDDP for esophageal cancer - Results of a randomized trial

Tomohiro Kaneta, Y. Takai, K. Nemoto, Y. Kakuto, Y. Ogawa, H. Ariga, S. Maruoka, T. Ishibashi, Y. Hosoi, S. Yamada

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16 Citations (Scopus)

Abstract

Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5mg/m2) (arm B). For arm B group, CDDP was infected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy/30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response raze of 25.0%) was observed in arm A and 91.7 % (complete response rate of 16.7 %) in arm B, respectively. The survival rate at 1 year was 23.8 % in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.

Original languageEnglish
Pages (from-to)2099-2104
Number of pages6
JournalJapanese Journal of Cancer and Chemotherapy
Volume24
Issue number14
Publication statusPublished - 1997

Keywords

  • CDDP
  • Esophageal cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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