Between 1994 and 1996, 24 patients with esophageal carcinoma were entered in a randomized clinical trial comparing radiotherapy (RT) only (arm A) versus RT and a daily low dose of CDDP (5mg/m2) (arm B). For arm B group, CDDP was infected within 30 min after irradiation. All patients were irradiated with a total dose of 60 Gy/30fr. at first, and some patients were boosted. An overall response rate of 75.0% (complete response raze of 25.0%) was observed in arm A and 91.7 % (complete response rate of 16.7 %) in arm B, respectively. The survival rate at 1 year was 23.8 % in arm A and 40.0% in arm B. Median survival time was 7 months in arm A and 9 months in arm B. Toxicity was acceptable and no significant difference was noted between arm A and arm B.
|Number of pages||6|
|Journal||Japanese Journal of Cancer and Chemotherapy|
|Publication status||Published - 1997|
- Esophageal cancer
ASJC Scopus subject areas
- Cancer Research