Effects of collateral vessel occlusion on oral glucose tolerance test in liver cirrhosis

Nobukazu Tanabe, Motoyasu Ishii, Yoshinori Sato, Takehiro Akahane, Nao Kobayashi, Hiroko Gama, Takao Iwasaki, Takayoshi Toyota

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Alterations in carbohydrate metabolism associated with liver cirrhosis are characterized by a high serum insulin level and prolonged hyperglycemia on oral glucose tolerance test (OGTT). We measured plasma glucose, immunoreactive insulin (IRI), and C-peptide immunoreactivity (CPR) levels during a 75-g OGTT before and after varices obliteration in 10 cirrhotic patients with gastric varices. After obliteration, the indocyanine green retention rate was decreased and the portal flow velocity was increased. A significant decline in plasma glucose and IRI levels was also noted on OGTT. Moreover, the plasma glucose and IRI levels declined at 90 and 120 min in OGTT while they increased progressively by 120 min before obliteration. The levels of CPR were similar before and after treatment. These results indicate that decreased portal flow due to extrahepatic shunt and consequent impairment of insulin metabolism play a role in glucose intolerance observed in cirrhotic patients and that shunt occlusion improves glucose metabolism.

    Original languageEnglish
    Pages (from-to)581-586
    Number of pages6
    JournalDigestive Diseases and Sciences
    Volume45
    Issue number3
    DOIs
    Publication statusPublished - 2000

    Keywords

    • Balloon-occluded retrograde transvenous obliteration
    • C-peptide immunoreactivity
    • Gastric varices
    • Immunoreactive insulin

    ASJC Scopus subject areas

    • Physiology
    • Gastroenterology

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