Effects of co-administration of tea epigallocatechin-3-gallate (EGCG) and caffeine on absorption and metabolism of EGCG in humans

Kiyotaka Nakagawa, Kayoko Nakayama, Miho Nakamura, Phumon Sookwong, Tsuyoshi Tsuduki, Hitoshi Niino, Fumiko Kimura, Teruo Miyazawa

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Based on the ratios of (-)-epigallocatechin-3-gallate (EGCG) and caffeine (CAF) levels found in commercial tea drinks, EGCG and CAF were co-administered to human volunteers at various EGCG/CAF ratios, and plasma EGCG was determined by high performance liquid chromatography with chemiluminescence detection. As for the results, in plasma taken after ingestion of a beverage containing 95 mg of EGCG alone, the area under the plasma EGCG concentration-time curve (AUC) was 857 ng-h/ml. A higher AUC (1,370 ng-h/ml) was observed when subjects ingested a beverage containing EGCG (95mg) and a low amount of CAF (40 mg). In the case of ingestion of a beverage containing EGCG (95 mg) and a high amount of CAF (180 mg), the AUC tended to be somewhat higher (1,165 ng-h/ml), but not significantly so, compared with the beverage with EGCG alone. These findings (modulation of plasma EGCG level by CAF) provide ideas for modulating the bioavailability of tea catechins, which can be applied to tea-related drinks and foods.

Original languageEnglish
Pages (from-to)2014-2017
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Caffeine
  • Human plasma
  • Tea catechins

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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