Effects of Chronically Administered Atrial Natriuretic Factor in Aldosterone-Infused Hypertensive Rats

Minoru Yasujima, Keishi Abe, Masayuki Kanazawa, Masahiro Kohzuki, Kazunori Yoshida, Masao Hiwatari, Tsuyoshi Saito, Shunichi Saso, Kaoru Yoshinaga

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the pathophysiological role of atrial natriuretic factors in mineralocorticoid hypertension, we studied the effects of chronic infusion of synthetic atrial natriuretic factor on blood pressure and sodium-water excretion in rats with aldosterone salt-induced hypertension. Administration of synthetic atrial natriuretic factor (150 μg/kg/day) to rats made hypertensive by 7-day infusion of aldosterone (100 μg/kg/day) and sodium loading with 1% NaCl as drinking water returned the blood pressure to control levels, and the anti-hypertensive effect was not associated with any changes in urine volume and urinary sodium excretion. These results indicate that atrial natriuretic factors may be involved in the regulation of blood pressure in mineralocorticoid hypertension, independent of the renal effects of these substances.

Original languageEnglish
Pages (from-to)1446-1449
Number of pages4
JournalJAPANESE CIRCULATION JOURNAL
Volume52
Issue number12
DOIs
Publication statusPublished - 1988

Keywords

  • Aldosterone
  • Atrial natriuretic factor
  • Experimental hypertension
  • Mineralocorticoid

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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