Effects of chlordimeform on the electrical activity of waxmoth larva foregut

Daisuke Yamamoto, Jun ichi Fukami

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Microelectrodes were used to study the action of chlordimeform on the foregut nerve-muscle system of waxmoth larvae, Galleria mellonella. Excitatory postsynaptic potentials evoked by nerve stimulation were reversibly depressed by 2 × 10-3M chlordimeform. All-or-none spikes elicited by transmembrane current pulses were affected by higher concentrations (up to 5 × 10-3M) of chlordimeform. The critical membrane potential for spiking was always increased, while in some cases the amplitude and the rate of rise of the spike was reduced. Chlordimeform at 5 × 10-3M had very little effect on the outward rectification and effective membrane resistance of these muscle fibers. These data suggest the primary action of chlordimeform, causing a disturbance of foregut activity, is an inhibition of the mechanisms which generate synaptic and action potentials.

    Original languageEnglish
    Pages (from-to)49-54
    Number of pages6
    JournalPesticide Biochemistry and Physiology
    Issue number1
    Publication statusPublished - 1979 Aug

    ASJC Scopus subject areas

    • Agronomy and Crop Science
    • Health, Toxicology and Mutagenesis


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