Effects of Chitosan Hydrolysates on Lipid Absorption and on Serum and Liver Lipid Concentration in Rats

Ikuo Ikeda; Michihiro Sugano; Katsuko Yoshida; Eiji Sasaki; Yasushi Iwamoto; Kouta Hatano

doi:10.1021/jf00027a016

Effects of Chitosan Hydrolysates on Lipid Absorption and on Serum and Liver Lipid Concentration in Rats

Ikuo Ikeda, Michihiro Sugano, Katsuko Yoshida, Eiji Sasaki, Yasushi Iwamoto, Kouta Hatano

Research output: Contribution to journal › Article

93 Citations (Scopus)

Abstract

The enzymatic hydrolysates of chitosan with average molecular weights range from 5000 to 20 000 and with low viscosity interfered with intestinal absorption of cholesterol in lymph fistulated rats and increased fecal excretion of neutral steroids in rats fed a cholesterol-enriched diet. The hydrolysates exerted a cholesterol-lowering activity, and it was more marked in the liver than in the serum. They also reduced liver triglyceride significantly. Chitosan hydrolysates with average molecular weights of 10 000–20 000 were as effective as high-viscous chitosan with a molecular weight of 50 000. The results indicate usability of low-viscosity chitosan hydrolysate as a hypocholesterolemic agent.

Original language	English
Pages (from-to)	431-435
Number of pages	5
Journal	Journal of Agricultural and Food Chemistry
Volume	41
Issue number	3
DOIs	https://doi.org/10.1021/jf00027a016
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

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10.1021/jf00027a016

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title = "Effects of Chitosan Hydrolysates on Lipid Absorption and on Serum and Liver Lipid Concentration in Rats",

abstract = "The enzymatic hydrolysates of chitosan with average molecular weights range from 5000 to 20 000 and with low viscosity interfered with intestinal absorption of cholesterol in lymph fistulated rats and increased fecal excretion of neutral steroids in rats fed a cholesterol-enriched diet. The hydrolysates exerted a cholesterol-lowering activity, and it was more marked in the liver than in the serum. They also reduced liver triglyceride significantly. Chitosan hydrolysates with average molecular weights of 10 000–20 000 were as effective as high-viscous chitosan with a molecular weight of 50 000. The results indicate usability of low-viscosity chitosan hydrolysate as a hypocholesterolemic agent.",

author = "Ikuo Ikeda and Michihiro Sugano and Katsuko Yoshida and Eiji Sasaki and Yasushi Iwamoto and Kouta Hatano",

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T1 - Effects of Chitosan Hydrolysates on Lipid Absorption and on Serum and Liver Lipid Concentration in Rats

AU - Ikeda, Ikuo

AU - Sugano, Michihiro

AU - Yoshida, Katsuko

AU - Sasaki, Eiji

AU - Iwamoto, Yasushi

AU - Hatano, Kouta

PY - 1993

Y1 - 1993

N2 - The enzymatic hydrolysates of chitosan with average molecular weights range from 5000 to 20 000 and with low viscosity interfered with intestinal absorption of cholesterol in lymph fistulated rats and increased fecal excretion of neutral steroids in rats fed a cholesterol-enriched diet. The hydrolysates exerted a cholesterol-lowering activity, and it was more marked in the liver than in the serum. They also reduced liver triglyceride significantly. Chitosan hydrolysates with average molecular weights of 10 000–20 000 were as effective as high-viscous chitosan with a molecular weight of 50 000. The results indicate usability of low-viscosity chitosan hydrolysate as a hypocholesterolemic agent.

AB - The enzymatic hydrolysates of chitosan with average molecular weights range from 5000 to 20 000 and with low viscosity interfered with intestinal absorption of cholesterol in lymph fistulated rats and increased fecal excretion of neutral steroids in rats fed a cholesterol-enriched diet. The hydrolysates exerted a cholesterol-lowering activity, and it was more marked in the liver than in the serum. They also reduced liver triglyceride significantly. Chitosan hydrolysates with average molecular weights of 10 000–20 000 were as effective as high-viscous chitosan with a molecular weight of 50 000. The results indicate usability of low-viscosity chitosan hydrolysate as a hypocholesterolemic agent.

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