The relation between the detailed chemical reaction model and detonation simulations is studied by performing the zero-, one-, and two-dimensional numerical analyses using several chemical reaction medels. The comparison of these reaction models at high pressure is performed to get the combustion characteristics such as the ignition delay time, laminar flame velocity, and their sensitivity analysis. The Petersen and Hanson model and Koshi model are chosen for the reaction models in the detonation simulation. Other models are used for the comparison of combustion characteristics only. The numerical results are compared with experimental results and are discussed about the better detailed chemical reaction model in the numerical simulations at high pressure conditions.