Effects of capsaicin treatment on nociception and structure of trigeminal nerve fibers in adult rats

Akiko Kato, Megumi Nakamura, Seishi Echigo, Yasuyuki Sasano

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Systemic capsaicin treatment has been used in animal research to eliminate sensory nerve function, but little is known about physiological and morphological effects. We investigated the time-dependent changes in nociception and the ultrastructure of sensory nerve fibers after administration of capsaicin in rats. Capsaicin treatment caused transient loss of sensitivity, but transmission electron microscopy showed no structural changes of trigeminal nerve fibers in capsaicin- treated rats as well as controls. These results suggest that the structural damage to sensory nerve fibers may not be a cause of the reduction of sensitivity.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Pages140-142
Number of pages3
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
DOIs
Publication statusPublished - 2012 Jan 1

Keywords

  • Adult rats
  • Capsaicin
  • Nociception
  • Transmission electron microscopy
  • Trigeminal nerve

ASJC Scopus subject areas

  • Dentistry(all)

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