Effects of C-type natriuretic peptide on renal vasoconstriction in dogs

Kozo Yoshida, Tsuyoshi Yamagata, Yuichi Tomura, Mizue Suzuki-Kusaba, Makoto Yoshida, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Intrarenal arterial infusion of C-type natriuretic peptide (CNP, 50 ng/kg per min) increased urine flow rate without affecting glomerular filtration rate. Intrarenal arterial bolus injection of angiotensin II (25, 50 and 100 ng) or of norepinephrine (0.25, 0.5 and 1.0 μg) reduced renal blood flow. The blood flow response induced by angiotensin II was slightly attenuated but the response induced by norepinephrine was unaffected during CNP infusion. These results suggest that exogenous CNP, even at the pharmacological dose that can induce diuresis, has little effect on the canine renal vasculature.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalEuropean Journal of Pharmacology
Volume338
Issue number2
DOIs
Publication statusPublished - 1997 Nov 5

Keywords

  • Angiotensin II
  • CNP (C-type natriuretic peptide)
  • Dog
  • Kidney
  • Norepinephirine
  • Vasoconstriction

ASJC Scopus subject areas

  • Pharmacology

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