TY - JOUR
T1 - Effects of C-type natriuretic peptide on renal vasoconstriction in dogs
AU - Yoshida, Kozo
AU - Yamagata, Tsuyoshi
AU - Tomura, Yuichi
AU - Suzuki-Kusaba, Mizue
AU - Yoshida, Makoto
AU - Hisa, Hiroaki
AU - Satoh, Susumu
PY - 1997/11/5
Y1 - 1997/11/5
N2 - Intrarenal arterial infusion of C-type natriuretic peptide (CNP, 50 ng/kg per min) increased urine flow rate without affecting glomerular filtration rate. Intrarenal arterial bolus injection of angiotensin II (25, 50 and 100 ng) or of norepinephrine (0.25, 0.5 and 1.0 μg) reduced renal blood flow. The blood flow response induced by angiotensin II was slightly attenuated but the response induced by norepinephrine was unaffected during CNP infusion. These results suggest that exogenous CNP, even at the pharmacological dose that can induce diuresis, has little effect on the canine renal vasculature.
AB - Intrarenal arterial infusion of C-type natriuretic peptide (CNP, 50 ng/kg per min) increased urine flow rate without affecting glomerular filtration rate. Intrarenal arterial bolus injection of angiotensin II (25, 50 and 100 ng) or of norepinephrine (0.25, 0.5 and 1.0 μg) reduced renal blood flow. The blood flow response induced by angiotensin II was slightly attenuated but the response induced by norepinephrine was unaffected during CNP infusion. These results suggest that exogenous CNP, even at the pharmacological dose that can induce diuresis, has little effect on the canine renal vasculature.
KW - Angiotensin II
KW - CNP (C-type natriuretic peptide)
KW - Dog
KW - Kidney
KW - Norepinephirine
KW - Vasoconstriction
UR - http://www.scopus.com/inward/record.url?scp=0030662008&partnerID=8YFLogxK
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U2 - 10.1016/S0014-2999(97)81940-1
DO - 10.1016/S0014-2999(97)81940-1
M3 - Article
C2 - 9455994
AN - SCOPUS:0030662008
VL - 338
SP - 131
EP - 134
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -