Effects of bone marrow stromal cell injection in an experimental glaucoma model

Saiyuu Yu, Teruyo Tanabe, Mari Dezawa, Hiroto Ishikawa, Nagahisa Yoshimura

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

We investigated if bone marrow stromal cells (BMSCs) transplanted into the vitreous body of a glaucoma model eye could be integrated in the host retina and also whether they could rescue the retinal ganglion cells (RGCs) from death induced by the elevated intraocular pressure. Glaucoma was induced in the right eye of adult Wistar rats by ligating the episcleral veins. The GFP-expressing BMSCs (GFP-BMSCs) were injected into the vitreous body of both the control and the glaucomatous eyes. After transplantation, GFP-BMSCs were mostly present along with the inner limiting membrane and only a few cells were integrated into the ganglion cell layer. At 2 or 4 weeks after transplantation, GFP-BMSCs were observed to express various trophic factors. The BMSCs injected glaucoma model eyes showed less reduction in the number of RGCs compared to the glaucomatous eyes with PBS injection. This study suggests that BMSC transplantation may be worthy as a neuroprotective tool to treat glaucoma.

Original languageEnglish
Pages (from-to)1071-1079
Number of pages9
JournalBiochemical and biophysical research communications
Volume344
Issue number4
DOIs
Publication statusPublished - 2006 Jun 16
Externally publishedYes

Keywords

  • Bone marrow stromal cell
  • Glaucoma
  • RGC
  • Transplantation
  • Trophic factor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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