Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats

Atsushi Takahashi; Kenji Onodera; Takashi Saito; Masato Sugawara; Hisashi Shinoda; Hideaki Mayanagi

doi:10.1016/j.ics.2005.06.102

Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats

Atsushi Takahashi, Kenji Onodera, Takashi Saito, Masato Sugawara, Hisashi Shinoda, Hideaki Mayanagi

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Abstract

Long-term treatment with antiepileptics has been known to cause a variety of bone disorders. The present study was undertaken to investigate effects of long-term administration of three antiepileptic agents (phenytoin, zonisamide and valproate) on bone metabolism in growing rats. The results showed that all three agents decreased the bone mineral density in both metaphysis and diaphysis. The magnitude of the decrease was greater in the metaphysis than diaphysis for zonisamide, but it was not for phenytoin and valproic acid. The above results showed that phenytoin, zonisamide and valproic acid could induce bone loss in growing rats. These phenomena would have some influences on development and progress of oral diseases.

Original language	English
Pages (from-to)	87-88
Number of pages	2
Journal	International Congress Series
Volume	1284
DOIs	https://doi.org/10.1016/j.ics.2005.06.102
Publication status	Published - 2005 Sep

Keywords

Antiepileptic agent
Bone disorder
Bone mineral density
Osteopenia

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.ics.2005.06.102

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title = "Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats",

abstract = "Long-term treatment with antiepileptics has been known to cause a variety of bone disorders. The present study was undertaken to investigate effects of long-term administration of three antiepileptic agents (phenytoin, zonisamide and valproate) on bone metabolism in growing rats. The results showed that all three agents decreased the bone mineral density in both metaphysis and diaphysis. The magnitude of the decrease was greater in the metaphysis than diaphysis for zonisamide, but it was not for phenytoin and valproic acid. The above results showed that phenytoin, zonisamide and valproic acid could induce bone loss in growing rats. These phenomena would have some influences on development and progress of oral diseases.",

keywords = "Antiepileptic agent, Bone disorder, Bone mineral density, Osteopenia",

author = "Atsushi Takahashi and Kenji Onodera and Takashi Saito and Masato Sugawara and Hisashi Shinoda and Hideaki Mayanagi",

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TY - JOUR

T1 - Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats

AU - Takahashi, Atsushi

AU - Onodera, Kenji

AU - Saito, Takashi

AU - Sugawara, Masato

AU - Shinoda, Hisashi

AU - Mayanagi, Hideaki

PY - 2005/9

Y1 - 2005/9

N2 - Long-term treatment with antiepileptics has been known to cause a variety of bone disorders. The present study was undertaken to investigate effects of long-term administration of three antiepileptic agents (phenytoin, zonisamide and valproate) on bone metabolism in growing rats. The results showed that all three agents decreased the bone mineral density in both metaphysis and diaphysis. The magnitude of the decrease was greater in the metaphysis than diaphysis for zonisamide, but it was not for phenytoin and valproic acid. The above results showed that phenytoin, zonisamide and valproic acid could induce bone loss in growing rats. These phenomena would have some influences on development and progress of oral diseases.

AB - Long-term treatment with antiepileptics has been known to cause a variety of bone disorders. The present study was undertaken to investigate effects of long-term administration of three antiepileptic agents (phenytoin, zonisamide and valproate) on bone metabolism in growing rats. The results showed that all three agents decreased the bone mineral density in both metaphysis and diaphysis. The magnitude of the decrease was greater in the metaphysis than diaphysis for zonisamide, but it was not for phenytoin and valproic acid. The above results showed that phenytoin, zonisamide and valproic acid could induce bone loss in growing rats. These phenomena would have some influences on development and progress of oral diseases.

KW - Antiepileptic agent

KW - Bone disorder

KW - Bone mineral density

KW - Osteopenia

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DO - 10.1016/j.ics.2005.06.102

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EP - 88

JO - International Congress Series

JF - International Congress Series

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ER -

Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats

Abstract

Keywords

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