Effects of antiepileptics phenytoin, zonisamide and valproate on bone metabolism in growing rats

Atsushi Takahashi, Kenji Onodera, Takashi Saito, Masato Sugawara, Hisashi Shinoda, Hideaki Mayanagi

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Long-term treatment with antiepileptics has been known to cause a variety of bone disorders. The present study was undertaken to investigate effects of long-term administration of three antiepileptic agents (phenytoin, zonisamide and valproate) on bone metabolism in growing rats. The results showed that all three agents decreased the bone mineral density in both metaphysis and diaphysis. The magnitude of the decrease was greater in the metaphysis than diaphysis for zonisamide, but it was not for phenytoin and valproic acid. The above results showed that phenytoin, zonisamide and valproic acid could induce bone loss in growing rats. These phenomena would have some influences on development and progress of oral diseases.

Original languageEnglish
Pages (from-to)87-88
Number of pages2
JournalInternational Congress Series
Volume1284
DOIs
Publication statusPublished - 2005 Sep

Keywords

  • Antiepileptic agent
  • Bone disorder
  • Bone mineral density
  • Osteopenia

ASJC Scopus subject areas

  • Medicine(all)

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